ArticleCell reports2020
Lactate Limits T Cell Proliferation via the NAD(H) Redox State.
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Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 231 papers.
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231citing papers in PubMed
25.4field-weighted citation impact, top 1% of its field
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Who cites it
231 citing papers in PubMed, 320 citations in OpenAlex.
- Lactate Signal: Modulator of Cellular Energy Production and Anabolism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Nanozyme-Mediated Cellular and Microenvironmental Metabolic Reprogramming for Boosting Cancer Immunotherapy.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Dissecting immunosuppressive microenvironment in chemotherapy-resistant colorectal cancer through single-cell transcriptomic analysis.Translational oncology · 2026Article
- Article
- Single-cell and spatial transcriptomics reveal lactate-active epithelial-immune cell crosstalk that reprograms the immune microenvironment in colorectal cancer.Translational oncology · 2026Article
- Lactate metabolism and protein lactylation in inflammatory and tumor microenvironments.Molecular biomedicine · 2026Review
- Review
- Metabolic rewiring of the dendritic cell-T cell axis: tumour-derived barriers and therapeutic opportunities.Experimental & molecular medicine · 2026Review
- Nrf2-mediated metabolic reprogramming drives regulatory T cell accumulation in hepatocellular carcinoma.Nature communications · 2026Article
- Immunological decoding of adult T cell leukemia - its cell of origin and oncogenesis.Biomarker research · 2026Review
- Dual roles of lactylation modification in gastric cancer: Crosstalk between metabolic reprogramming and epigenetic regulation (Review).Oncology reports · 2026Review
- Beyond a waste product: lactate as a master metabolite dictating anti-tumor T-cell fate.Cell death & disease · 2026Review
- Lactate-Primed NETosis Modulates Hepatic Regeneration During Acute Liver Failure via the TLR9/KLF15/AJUBA Axis.Cell proliferation · 2026Article
- Review
- Review
- Glycolytic lactylation modulates cell death decisions in diabetic kidney disease: Metabolic‑epigenetic interplay between ferroptosis and autophagy in fibrotic remodeling (Review).International journal of molecular medicine · 2026Review
- Mesoporous polydopamine nanoplatform enhances IL-2 immunotherapy for hepatocellular carcinoma via mild photothermal therapy and lactate regulation.Asian journal of pharmaceutical sciences · 2026Article
- Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- IDH2 lactylation regulates mitochondrial dysfunction injury induced by myocardial ischemia‑reperfusion via the AMPK signaling pathway.International journal of molecular medicine · 2026Article
- Prognostic Value of the C-PLAN Index in Advanced Esophageal Squamous Cell Carcinoma Patients Treated With Immune Checkpoint Inhibitors.The Kaohsiung journal of medical sciences · 2026Article
171 more citing papers are in PubMed but not listed here.
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Authors and funding
23 authors at 4 institutions in 1 country.
William J QuinnDepartment of Physiology and Institute of Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jing JiaoDivision of Nephrology and Department of Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA 19104, USA.
Tara TeSlaaLewis Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Washington Road, Princeton, NJ 08544, USA.
Jason StadanlickDivision of Thoracic Surgery, Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Zhonglin WangDepartment of Surgery, Penn Transplant Institute, Perelman School of Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA 19104, USA.
Liqing WangDivision of Transplant Immunology, Department of Pathology and Laboratory Medicine and Biesecker Center for Pediatric Liver Disease, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA 19104, USA.
Tatiana AkimovaDivision of Transplant Immunology, Department of Pathology and Laboratory Medicine and Biesecker Center for Pediatric Liver Disease, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA 19104, USA.
Alessia AngelinCenter for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Patrick M SchäferCenter for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Michelle D CullyDivision of Nephrology and Department of Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA 19104, USA.
Caroline PerryDepartment of Physiology and Institute of Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, PA 19104, USA.
Piotr K KopinskiCenter for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Lili GuoPenn SRP Center, Center of Excellence in Environmental Toxicology and Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ian A BlairPenn SRP Center, Center of Excellence in Environmental Toxicology and Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Louis R GhanemDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Michael S LeibowitzDivision of Oncology, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Wayne W HancockDivision of Transplant Immunology, Department of Pathology and Laboratory Medicine and Biesecker Center for Pediatric Liver Disease, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA 19104, USA.
Edmund K MoonDepartment of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Matthew H LevineDepartment of Surgery, Penn Transplant Institute, Perelman School of Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA 19104, USA.
Evgeniy B EruslanovDivision of Thoracic Surgery, Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Douglas C WallaceCenter for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Joseph A BaurDepartment of Physiology and Institute of Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ulf H BeierDivision of Nephrology and Department of Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: beieru@email.chop.edu.
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · USTranslational Therapeutics (United States) · USPrinceton University · US
Funding
Transgenic and mutant animalP01AI073489 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI KATSUMATA, MAKOTO · 2008 to 2012
$7.1MMITOCHONDRIAL INBORN ERRORS OF METABOLISMR01NS021328 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI WALLACE, DOUGLAS C · 1985 to 2017
$6.5MTargeting NAD Metabolism to Improve Glucose Homeostasis in Obesity and AgingR01DK098656 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Joseph A. Baur · 2013 to 2026
$6.1MImmune System Development and RegulationT32AI055428 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ALLMAN, DAVID M, OLIVER, PAULA MARIA · 2003 to 2025
$4.2MA MITOCHONDRIAL-INTERNEURONAL HYPOTHESIS OF AUTISMR01MH108592 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI WALLACE, DOUGLAS C · 2016 to 2020
$3.1MMouse models for mitochondrial disorders caused by mutations in mtDNAR01OD010944 · OD · UNIVERSITY OF SOUTH ALABAMA · PI ALEXEYEV, MIKHAIL F., WALLACE, DOUGLAS C · 2012 to 2020
$2.6MMolecular Mechanisms of Rapamycin's Effects on Health and LongevityR01AG043483 · NIA · UNIVERSITY OF PENNSYLVANIA · PI BAUR, JOSEPH A. · 2013 to 2017
$2.0MHDAC2 Inhibition Mitigates Renal Ischemia Reperfusion InjuryR01DK106243 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI LEVINE, MATTHEW HOWARD · 2016 to 2020
$1.8MTumor-associated neutrophils in human lung cancerR01CA187392 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ERUSLANOV, EVGENIY · 2016 to 2020
$1.8MTargeting Sirtuin-1 to enhance Foxp3+ regulatory T-cell functionK08AI095353 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI BEIER, ULF · 2011 to 2015
$650kANTI-INFLAMMATORY EFFECTS OF TARGETING THE HDAC6/HSP90 PATHWAYR56AI095276 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI HANCOCK, WAYNE WILLIAM · 2011 to 2011
$209kQuantitative measurement of whole-body glycogen metabolism and gluconeogenic fluxF32DK118856 · NIDDK · PRINCETON UNIVERSITY · PI TESLAA, TARA A. · 2019 to 2021
$195kHoward Hughes Medical InstituteNCI NIH HHS R01 CA187392NIAID NIH HHS K08 AI095353NIAID NIH HHS P01 AI073489NIAID NIH HHS R56 AI095276NIAID NIH HHS T32 AI055428NIA NIH HHS R01 AG043483NIDDK NIH HHS F32 DK118856NIDDK NIH HHS R01 DK098656NIDDK NIH HHS R01 DK106243NIH HHS R01 OD010944NIMH NIH HHS R01 MH108592NINDS NIH HHS R01 NS021328
Abstract
Immune cell function is influenced by metabolic conditions. Low-glucose, high-lactate environments, such as the placenta, gastrointestinal tract, and the tumor microenvironment, are immunosuppressive, especially for glycolysis-dependent effector T cells. We report that nicotinamide adenine dinucleotide (NAD
Indexed as
Cell ProliferationHumansLactic AcidNADOxidation-ReductionLactic AcidNAD3-phosphoglycerateglycolysisimmunometabolismlactate metabolismnicotinamide adenine dinucleotideredox metabolismserineT cell metabolism
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