ArticleCell reports2020
A Comparison of Dopaminergic and Cholinergic Populations Reveals Unique Contributions of VTA Dopamine Neurons to Short-Term Memory.
Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- VTA dopamine neuron activity produces spatially organized value representations.bioRxiv : the preprint server for biology · 2025Article
- Blood oxygenation level-dependent responses in neuromodulatory nuclei and their associations with attention and memory across age groups.Neurobiology of aging · 2025Article
- Region-specific nucleus accumbens dopamine signals encode distinct aspects of avoidance learning.Current biology : CB · 2025Article
- A statistical framework for analysis of trial-level temporal dynamics in fiber photometry experiments.eLife · 2025Article
- A Statistical Framework for Analysis of Trial-Level Temporal Dynamics in Fiber Photometry Experiments.bioRxiv : the preprint server for biology · 2024Article
- Distinct dynamics and intrinsic properties in ventral tegmental area populations mediate reward association and motivation.Cell reports · 2024Article
- A feature-specific prediction error model explains dopaminergic heterogeneity.Nature neuroscience · 2024Article
- Contributions of cortical neuron firing patterns, synaptic connectivity, and plasticity to task performance.Nature communications · 2024Article
- Memory-specific encoding activities of the ventral tegmental area dopamine and GABA neurons.eLife · 2024Article
- Activity-dependent constraints on catecholamine signaling.Cell reports · 2023Article
- Article
- Contexts facilitate dynamic value encoding in the mesolimbic dopamine system.bioRxiv : the preprint server for biology · 2023Article
- Overlapping representations of food and social stimuli in VTA dopamine neurons.bioRxiv : the preprint server for biology · 2023Article
- Article
- A dopamine gradient controls access to distributed working memory in the large-scale monkey cortex.Neuron · 2021Article
- Highlights from the Era of Open Source Web-Based Tools.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
We systematically compare the contributions of two dopaminergic and two cholinergic ascending populations to a spatial short-term memory task in rats. In ventral tegmental area dopamine (VTA-DA) and nucleus basalis cholinergic (NB-ChAT) populations, trial-by-trial fluctuations in activity during the delay period relate to performance with an inverted-U, despite the fact that both populations have low activity during that time. Transient manipulations reveal that only VTA-DA neurons, and not the other three populations we examine, contribute causally and selectively to short-term memory. This contribution is most significant during the delay period, when both increases and decreases in VTA-DA activity impair short-term memory. Our results reveal a surprising dissociation between when VTA-DA neurons are most active and when they have the biggest causal contribution to short-term memory, and they also provide support for classic ideas about an inverted-U relationship between neuromodulation and cognition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.