Evidence map›Paper›PMID 33326623›Full record

Trial reportAlimentary pharmacology & therapeutics2021

Hyperbaric oxygen therapy for the treatment of perianal fistulas in 20 patients with Crohn's disease.

Corine A Lansdorp, Krisztina B Gecse, Christianne J Buskens, Mark Löwenberg, Jaap Stoker, Willem A Bemelman, Geert R A M D'Haens, Rob A van Hulst

Open access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Alimentary pharmacology & therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. La Tunisie medicale · 2024
    Review
  15. Review
  16. Perianal fistulizing Crohn's disease: Current perspectives on diagnosis, monitoring and management with a focus on emerging therapies.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024
    Review
  17. Review
  18. Refractory Crohn's Disease: Perspectives, Unmet Needs and Innovations.Clinical and experimental gastroenterology · 2024
    Review
  19. Article
  20. Emerging treatment strategies in wound care.International wound journal · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Corine A LansdorpDepartment of Anesthesiology/Hyperbaric Medicine, Amsterdam UMC, location AMC, Amsterdam, The Netherlands.ORCID 0000-0001-9395-4003
Krisztina B GecseDepartment of Gastroenterology and Hepatology, Amsterdam UMC, location AMC, Amsterdam, The Netherlands.
Christianne J BuskensDepartment of Surgery, Amsterdam UMC, location AMC, Amsterdam, The Netherlands.
Mark LöwenbergDepartment of Gastroenterology and Hepatology, Amsterdam UMC, location AMC, Amsterdam, The Netherlands.
Jaap StokerDepartment of Radiology and Nuclear Medicine, Amsterdam UMC, location AMC, Amsterdam, The Netherlands.
Willem A BemelmanDepartment of Surgery, Amsterdam UMC, location AMC, Amsterdam, The Netherlands.
Geert R A M D'HaensDepartment of Gastroenterology and Hepatology, Amsterdam UMC, location AMC, Amsterdam, The Netherlands.
Rob A van HulstDepartment of Anesthesiology/Hyperbaric Medicine, Amsterdam UMC, location AMC, Amsterdam, The Netherlands.
Amsterdam University Medical Centers · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPositive effects of hyperbaric oxygen on perianal fistulas in Crohn's disease have been reported.

aimTo assess efficacy, safety and feasibility of hyperbaric oxygen in Crohn's disease patients with therapy-refractory perianal fistulas.

methodsTwenty consecutive patients were recruited at the out-patient fistula clinic of the Amsterdam UMC. Crohn's disease patients with high perianal fistula(s) failing conventional treatment for over 6 months were included. Exclusion criteria were presence of a stoma, rectovaginal fistula(s) and recent changes in treatment regimens. Patients received treatment with 40 hyperbaric oxygen sessions and outcome parameters were assessed at Week 16.

resultsSeven women and 13 men were included (median age 34 years). At Week 16, median scores of perianal disease activity index and modified van Assche index (co-primary outcome parameters) decreased from 7.5 (95% CI 6-9) to 4 (95% CI 3-6, P < 0.001), and from 9.2 (95% CI 7.3-11.2) to 7.3 (95% CI 6.9-9.7, P = 0.004) respectively. Perianal disease activity index scores ≤4 (representing inactive perianal disease) were observed in 13/20 patients (65%). Twelve patients showed a clinical response (60%) and four (20%) clinical remission, assessed with fistula drainage assessment. Median C-reactive protein and faecal calprotectin levels decreased from 4.2 mg/mL (95% CI 1.6-8) to 2.2 (95% CI 0.9-4.3, P = 0.003) and from 399 µg/g (95% CI 52-922) to 31 (95% CI 16-245, P = 0.001), respectively.

conclusionsWe found significant clinical, radiological and biochemical improvement in Crohn's disease patients with therapy-refractory perianal fistulas after treatment with hyperbaric oxygen. CLINICAL

trial registrationwww.trialregister.nl/trial/6489.

Indexed as

Crohn DiseaseHyperbaric OxygenationRectal FistulaAdultDrainageFemaleHumansMaleTreatment Outcome

Identifiers

PMID33326623
PMCPMC7898636
OpenAlexW3112463741

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.