Evidence map›Paper›PMID 33326581›Full record

ReviewThe Journal of infectious diseases2021

The Gut Microbiome as a Reservoir for Antimicrobial Resistance.

Winston E Anthony, Carey-Ann D Burnham, Gautam Dantas, Jennie H Kwon

Open access · bronzeAbstract readReview
In one paragraph

Review in The Journal of infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 1 synthesis or guideline pooled it, 145 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Gut microbiota in health and disease.Molecular biomedicine · 2026
    Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Oral and plasma microbiome in the context of acute febrile illness.medRxiv : the preprint server for health sciences · 2026
    Article
  17. Article
  18. Review
  19. Article
  20. Review

35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Winston E AnthonyThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine in St. Louis, St Louis, Missouri, USA.
Carey-Ann D BurnhamDepartment of Pathology and Immunology, Washington University School of Medicine in St. Louis, St Louis, Missouri, USA.
Gautam DantasThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine in St. Louis, St Louis, Missouri, USA.ORCID 0000-0003-0455-8370
Jennie H KwonDepartment of Medicine, Washington University School of Medicine in St. Louis, St Louis, Missouri, USA.ORCID 0000-0002-7824-6276
Washington University in St. Louis · US

Funding

Longitudinal Analysis of the Fecal Microbiome and Resistome of Patients with Multidrug-Resistant Urinary Tract Infections and Predictors of RecurrenceK23AI137321 · NIAID · WASHINGTON UNIVERSITY · PI KWON, JENNIE H · 2019 to 2022
$675k
NIAID NIH HHS K23 AI137321
6 · The paper itself

Abstract

This review will consider the gut as a reservoir for antimicrobial resistance, colonization resistance, and how disruption of the microbiome can lead to colonization by pathogenic organisms. There is a focus on the gut as a reservoir for β-lactam and plasmid-mediated quinolone resistance. Finally, the role of functional metagenomics and long-read sequencing technologies to detect and understand antimicrobial resistance genes within the gut microbiome is discussed, along with the potential for future microbiome-directed methods to detect and prevent infection.

Indexed as

Anti-Infective AgentsBacterial InfectionsDrug Resistance, MicrobialGastrointestinal MicrobiomeGastrointestinal TractGenes, MicrobialHumansMetagenomicsPlasmidsAnti-Infective Agentsantibiotic resistanceantimicrobial resistanceMicrobiomeresistome

Identifiers

PMID33326581
PMCPMC8206794
OpenAlexW3116113567

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.