Evidence map›Paper›PMID 33326565›Full record

ArticleThe Journal of infectious diseases2021

Mechanisms of Colonization Resistance Against Clostridioides difficile.

Colleen M Pike, Casey M Theriot

2 registry-linked trialsAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06106698 recruitingnot on this mapstarted 2023, after this paper: background citation

Washed Microbiota Transplantation for Clostridioides Difficile Infection: a Real World Research

TypeobservationalSponsorThe Second Hospital of Nanjing Medical UniversityRan2023 to 2029Enrolled100ConditionsClostridioides Difficile InfectionArmsWMT
NCT06836427 early_phase1not yet recruitingnot on this mapstarted 2025, after this paper: background citation

CMTS0929 for Clostridioides Difficile Infection: a Prospective, Open-label, Single-arm Clinical Study

TypeinterventionalSponsorThe Second Hospital of Nanjing Medical UniversityRan2025 to 2030Enrolled12ConditionsClostridioides Difficile InfectionArmsCMTS0929
3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Trial
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  8. A set of genetic tools for use inMicrobiology (Reading, England) · 2026
    Article
  9. Review
  10. Article
  11. Article
  12. Article
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  15. Article
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  19. Advances in Fecal Microbiota Transplantation for Gut Dysbiosis-Related Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Colleen M PikeDepartment of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
Casey M TheriotDepartment of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.

Funding

Targeted bacterial restoration of colonization resistance against C. difficileR35GM119438 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI THERIOT, CASEY MICHELLE · 2016 to 2020
$1.6M
NIGMS NIH HHS R35 GM119438
6 · The paper itself

Abstract

Clostridioides difficile is an urgent antimicrobial-resistant bacterium, causing mild to moderate and sometimes life-threatening disease. Commensal gut microbes are critical for providing colonization resistance against C difficile and can be leveraged as non-antibiotic alternative therapeutics for the prevention and treatment of C difficile infection.

Indexed as

AnimalsAnti-Bacterial AgentsAntibiosisBile Acids and SaltsClostridioides difficileClostridium InfectionsFatty Acids, VolatileGastrointestinal MicrobiomeHumansNutrientsAnti-Bacterial AgentsBile Acids and SaltsFatty Acids, VolatileNutrientsbacteriabile acidsClostridioides difficilemicrobiotashort-chain fatty acids

Identifiers

PMID33326565
PMCPMC8206795

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.