ArticlePloS one2020
Piece-wise linear models of biological systems-Application, analysis, and comparison with nonlinear models using the example of the p53 regulatory module.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Structure-Function Relationship in Keratoconus: Spatial and Depth Vision.Translational vision science & technology · 2023Article
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Authors and funding
2 authors.
Funding
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Abstract
In this paper, we propose to use a linear system with switching methodology for description and analysis of complex biological systems. We show advantages of the proposed approach over the one usually used, which is based on ODE. We propose the detailed methodology of a full analysis of developed models, including analytical determination of the location and type of equilibrium points, finding an analytical solution, stability and bifurcation analysis. We illustrate the above with the example of the well-known p53 signalling pathway comparing the results with the results of a nonlinear, ODE-based version of the proposed model. The complex methodology proposed by us, especially due to the definition of model structure, which is easy to understand for biologists and medics, may be a bridge for closer cooperation between them and engineers in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.