Evidence map›Paper›PMID 33326316›Full record

Trial reportHuman vaccines & immunotherapeutics2021

Immunogenicity and safety of a hexavalent pediatric vaccine in HIV-exposed infected and uninfected infants in Republic of South Africa.

Anthonet Koen, Shabir Madhi, Olga Lyabis, Emmanuel Vidor, Beverley Cowper, Thinus Marais, Dhaval Patel, Claire Vigne

Open access · bronzeAbstract readClinical Trial, Phase IIIRandomized Controlled Trial
In one paragraph

Trial report in Human vaccines & immunotherapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Review
  3. Clinical microbiology reviews · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Anthonet KoenMedical Research Council: Vaccines and Infectious Diseases Analytical Research Unit, Faculty of Health Science, University of the Witwatersrand, Johannesburg, South Africa.
Shabir MadhiMedical Research Council: Vaccines and Infectious Diseases Analytical Research Unit, Faculty of Health Science, University of the Witwatersrand, Johannesburg, South Africa.ORCID 0000-0002-7629-0636
Olga LyabisSanofi Pasteur, Lyon, France.ORCID 0000-0001-9615-0123
Emmanuel VidorSanofi Pasteur, Lyon, France.
Beverley CowperSanofi Pasteur, Johannesburg, South Africa.
Thinus MaraisSanofi Pasteur, Johannesburg, South Africa.ORCID 0000-0002-0680-3934
Dhaval PatelSanofi Pasteur, Swiftwater, PA, USA.ORCID 0000-0002-7718-2506
Claire VigneSanofi Pasteur, Lyon, France.
Sanofi (France) · FRUniversity of the Witwatersrand · ZASanofi (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human immunodeficiency virus (HIV)-exposed infants may be at increased risk of vaccine-preventable disease. This study was conducted as a post-licensure commitment in this population to evaluate the primary series, antibody persistence, and booster response to a licensed fully liquid hexavalent vaccine containing diphtheria (D), tetanus (T), acellular pertussis (aP), inactivated poliovirus (IPV), hepatitis B (HB), and

Indexed as

Haemophilus VaccinesHIV InfectionsAntibodies, BacterialAntibodies, ViralChildDiphtheria-Tetanus-Pertussis VaccineHepatitis B VaccinesHumansImmunization ScheduleImmunization, SecondaryInfantPoliovirus Vaccine, InactivatedSouth AfricaVaccines, CombinedAntibodies, BacterialAntibodies, ViralDiphtheria-Tetanus-Pertussis VaccineHaemophilus VaccinesHepatitis B VaccinesPoliovirus Vaccine, InactivatedVaccines, Combinedboosterhexavalenthistorical comparisonHIV-exposedHIV-infectedprimary seriesvaccine

Identifiers

PMID33326316
PMCPMC8115757
OpenAlexW3110736792

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.