ArticleAmerican journal of hematology2021
A novel genetic variant in PTGS1 affects N-glycosylation of cyclooxygenase-1 causing a dominant-negative effect on platelet function and bleeding diathesis.
Open access · bronzeAbstract readCase ReportsLetter
In one paragraph
Article in American journal of hematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Molecular Pathogenesis of Inherited Platelet Dysfunction.Biomolecules · 2025Review
- Src-related thrombocytopenia: a fine line between a megakaryocyte dysfunction and an immune-mediated disease.Blood advances · 2022Article
- Inherited Platelet Disorders: An Updated Overview.International journal of molecular sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors at 8 institutions in 3 countries.
Verónica Palma-BarquerosServicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, Murcia, Spain.
Marilena CrescenteCentre for Immunobiology, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University London, London, UK.
María Eugenia de la MorenaServicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, Murcia, Spain.
Melissa V ChanCentre for Immunobiology, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University London, London, UK.
Elena AlmarzaDivision of Hematopoietic Innovative Therapies, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas (CIEMAT)/Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) and Advanced Therapies Unit, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD/UAM), Madrid, Spain.
Nuria RevillaServicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, Murcia, Spain.
Natalia BohdanServicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, Murcia, Spain.
Antonia MiñanoServicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, Murcia, Spain.
José PadillaServicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, Murcia, Spain.
Harriet E AllanCentre for Immunobiology, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University London, London, UK.
Tania MaffucciCentre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Matthew L EdinNational Institutes of Health, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, North Carolina, USA.
Darryl C ZeldinNational Institutes of Health, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, North Carolina, USA.
Cristina Mesa-NuñezDivision of Hematopoietic Innovative Therapies, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas (CIEMAT)/Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) and Advanced Therapies Unit, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD/UAM), Madrid, Spain.
Carlos DamianDivision of Hematopoietic Innovative Therapies, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas (CIEMAT)/Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) and Advanced Therapies Unit, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD/UAM), Madrid, Spain.
Ana Marín-QuilezIBSAL, IBMCC, CIC, Universidad de Salamanca-CSIC, Salamanca, Spain.
Rocío BenitoIBSAL, IBMCC, CIC, Universidad de Salamanca-CSIC, Salamanca, Spain.
Irene Martínez-MartínezServicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, Murcia, Spain.
Nuria BermejoServicio de Hematología, Hospital San Pedro de Alcántara, Complejo Universitario de Cáceres, Cáceres, Spain.
Ignacio Casas-AvilesServicio de Hematología, Hospital San Pedro de Alcántara, Complejo Universitario de Cáceres, Cáceres, Spain.
Agustín Rodríguez-AlenServicio de Hematología y Hemoterapia, Hospital Virgen de la Salud, Complejo Hospitalario de Toledo, Toledo, Spain.
José R González-PorrasDepartamento de Hematología, Hospital Universitario de Salamanca, Salamanca-IBSAL, Salamaca, Spain.
Jesús María Hernández-RivasIBSAL, IBMCC, CIC, Universidad de Salamanca-CSIC, Salamanca, Spain.
Vicente VicenteServicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, Murcia, Spain.
Javier CorralServicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, Murcia, Spain.
María L LozanoServicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, Murcia, Spain.ORCID 0000-0003-3148-7037
Timothy D WarnerCentre for Immunobiology, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University London, London, UK.
José María BastidaDepartamento de Hematología, Hospital Universitario de Salamanca, Salamanca-IBSAL, Salamaca, Spain.
José RiveraServicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, Murcia, Spain.ORCID 0000-0003-4225-6840
Centro Regional de Hemodonación · ESQueen Mary University of London · GBCentre for Biomedical Network Research on Rare Diseases · ESUniversidad de Salamanca · ESHospital San Pedro de Alcántara · ESInstituto de Investigación Biomédica de Salamanca · ESNational Institutes of Health · USHospital Virgen de la Salud · ES
Funding
Alterations In Pulmonary Immune Function And Host Resistance In COX Null MiceZIAES025043 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI ZELDIN, DARRYL C · 2009 to 2025
$11.7MP450 Arachidonate EpoxygenasesZ01ES025034 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI ZELDIN, DARRYL C · 1995 to 2008
$2.2MBritish Heart Foundation PG/17/40/33028Intramural NIH HHS Z01 ES025034
Abstract
PubMed holds no abstract for this paper.
Indexed as
Loss of Function MutationMutation, MissenseAdolescentAsian PeopleCyclooxygenase 1FemaleGenes, DominantGlycosylationHEK293 CellsHemorrhagic DisordersHeterozygoteHumansPhenotypePlatelet ActivationProtein Processing, Post-TranslationalCyclooxygenase 1PTGS1 protein, human
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.