Evidence map›Paper›PMID 33325772›Full record

ArticleEnvironmental health perspectives2020

Environmental Cadmium and Mortality from Influenza and Pneumonia in U.S. Adults.

Sung Kyun Park, Coralynn Sack, Matti J Sirén, Howard Hu

Open access · diamondAbstract read
In one paragraph

Article in Environmental health perspectives, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Aryl hydrocarbon receptor activation alters emergency hematopoiesis during influenza A virus infection.Toxicological sciences : an official journal of the Society of Toxicology · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Sung Kyun ParkDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Coralynn SackDepartment of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle, Washington, USA.
Matti J SirénJorma Gallen-Kallela Memorial Research Library, Helsinki, Finland.
Howard HuDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
University of Michigan · USUniversity of Southern California · USUniversity of Washington · US

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Sheela Sathyanarayana · 1995 to 2026
$42.5M
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
The Role of Airway Morphology in Environmental LungDiseasesK23ES030725 · NIEHS · UNIVERSITY OF WASHINGTON · PI SACK, CORALYNN SHAYNA · 2019 to 2023
$835k
NIEHS NIH HHS K23 ES030725NIEHS NIH HHS P30 ES007033NIEHS NIH HHS P30 ES007048NIEHS NIH HHS P30 ES017885
6 · The paper itself

Abstract

backgroundEnvironmental cadmium exposure is widespread. In humans, cadmium is poorly excreted, triggers pulmonary inflammation, reduces pulmonary function, and enhances lung injury by respiratory syncytial virus.

objectivesWe examined the association of cadmium burden with mortality related to influenza or pneumonia.

methodsThis prospective analysis of the National Health and Nutrition Examination Survey (NHANES) included 7,173 and 8,678 participants

resultsIn NHANES-III, after adjustment for sex, race/ethnicity, education, body mass index, serum cholesterol, hypertension, and NHANES phase (or cycle), the HR comparing influenza or pneumonia mortality among participants with creatinine-corrected urinary cadmium in the 80th vs. 20th percentile was 1.15 (95% CI: 1.05, 1.26; DISCUSSION: Among middle-aged and older adults in the United States, higher cadmium burdens are associated with higher mortality from influenza or pneumonia. This raises the possibility that cadmium may worsen outcomes from COVID-19 infections. https://doi.org/10.1289/EHP7598.

Indexed as

SARS-CoV-2AgedAged, 80 and overCadmiumCOVID-19Environmental ExposureEnvironmental PollutantsFemaleHumansInfluenza, HumanMaleMiddle AgedNutrition SurveysPneumoniaProportional Hazards ModelsProspective StudiesCadmiumEnvironmental Pollutants

Identifiers

PMID33325772
PMCPMC7739956
OpenAlexW3110833492

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.