Trial reportHuman brain mapping2021
Cardiorespiratory fitness, hippocampal subfield volumes, and mnemonic discrimination task performance in aging.
Trial report in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Aerobic Exercise, Neurotrophins, and fMRI of Hippocampal Function and Structure
Feasibility of Using Physical Activity Monitoring for Enhancing Cognition in Healthy Seniors
The Entorhinal Cortex and Aerobic Exercise in Aging
Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Effects of web-based adapted physical activity on hippocampal plasticity, cardiorespiratory fitness, symptoms, and cardiometabolic markers in patients with schizophrenia: a randomized, controlled study.European archives of psychiatry and clinical neuroscience · 2024Trial
- Hippocampal subfield plasticity is associated with improved spatial memory.Communications biology · 2024Trial
- Cardiorespiratory fitness, hippocampal subfield volumes, and mnemonic discrimination task performance in aging.Human brain mapping · 2021Trial
- The effects of hippocampal dentate gyrus lesions on categorical face perception.Attention, perception & psychophysics · 2026Article
- No significant association between self-reported physical activity and brain volumes in women and men from five European cohorts.Scientific reports · 2025Article
- Exercise Benefits Dentate Gyrus Function: Bridging from Animal Models to Human High-Resolution Functional MRI of Pattern Separation.Advances in neurobiology · 2025Review
- Engagement in moderate-intensity physical activity supports overnight memory retention in older adults.Scientific reports · 2024Article
- Cardiorespiratory fitness is associated with cortical thickness of medial temporal brain areas associated with spatial cognition in young but not older adults.The European journal of neuroscience · 2024Article
- Cardiorespiratory fitness, hippocampal subfield morphology, and episodic memory in older adults.Frontiers in aging neuroscience · 2024Article
- Plasma concentrations of anti-inflammatory cytokine TGF-β are associated with hippocampal structure related to explicit memory performance in older adults.Journal of neural transmission (Vienna, Austria : 1996) · 2023Article
- Fitness is positively associated with hippocampal formation subfield volumes in schizophrenia: a multiparametric magnetic resonance imaging study.Translational psychiatry · 2022Article
- Cardiorespiratory fitness is associated with fMRI signal in right cerebellum lobule VIIa Crus I and II during spatial navigation in older adult women.Frontiers in aging neuroscience · 2022Article
- Daily-Life Physical Activity of Healthy Young Adults Associates With Function and Structure of the Hippocampus.Frontiers in human neuroscience · 2022Article
- Beneficial effects of foreign language learning and aerobic exercise on dentate gyrus volume and mnemonic discrimination in healthy older adults: Results from a randomized controlled trial.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Aging and exercise have opposing effects on mnemonic discrimination task performance, which putatively taxes pattern separation mechanisms reliant on the dentate gyrus (DG) subfield of the hippocampus. In young adults, increasing cardiorespiratory fitness (CRF) has been shown to improve mnemonic discrimination task performance and increase left anterior DG/CA3 volume. It is unknown how these variables interact in cognitive aging, yet this knowledge is critical, given the established effects of aging on hippocampal plasticity. To investigate these relationships, 65 older adults (aged 55-85 years) completed a submaximal treadmill test to estimate CRF, a mnemonic discrimination task, and a high-resolution MRI scan to determine hippocampal subfield volumes. Our older adult sample demonstrated the lowest task accuracy in the condition with the greatest stimuli similarity and left DG/CA3 body volume significantly predicted accuracy in this condition. Our results did not provide support for relationships between CRF and task accuracy or CRF and DG/CA3 volume as evidenced in studies of young adults. Instead, CRF predicted bilateral subiculum volume in older adult women, not men. Altogether, these findings provide further support for a role of the DG in behavioral pattern separation in humans and suggest that CRF may have differential effects on hippocampal subfield integrity in older adult men and women. ClinicalTrials.gov identifiers: (a) Neuroimaging Study of Exercise and Memory Function, NCT02057354; (b) The Entorhinal Cortex and Aerobic Exercise in Aging, NCT02775760; (c) Physical Activity and Cognition Study, NCT02773121.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.