ArticleClinical and experimental dental research2021
Chemical composition and antibacterial activity of Berberis vulgaris (barberry) against bacteria associated with caries.
Article in Clinical and experimental dental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Berberine in oral diseases: molecular mechanisms and therapeutic implications.Frontiers in pharmacology · 2026Review
- Medicinal Plants Against Dental Caries: Research and Application of Their Antibacterial Properties.Plants (Basel, Switzerland) · 2025Review
- Natural Food Colorant Obtained from WildFoods (Basel, Switzerland) · 2025Article
- Prospects of nanotechnology and natural products for cancer and immunotherapy.Beilstein journal of nanotechnology · 2025Review
- The Inhibitory Effect ofMolecules (Basel, Switzerland) · 2024Article
- The inhibitory effect of berberine chloride hydrate onMicrobiology spectrum · 2023Article
- Elucidating Berberine's Therapeutic and Photosensitizer Potential through Nanomedicine Tools.Pharmaceutics · 2023Review
- CuO-TiOBioinorganic chemistry and applications · 2022Article
- Plant-Derived Substances with Antibacterial, Antioxidant, and Flavoring Potential to Formulate Oral Health Care Products.Biomedicines · 2021Review
- Chemical composition and antibacterial activity of Berberis vulgaris (barberry) against bacteria associated with caries.Clinical and experimental dental research · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this in-vitro study was to determine the antimicrobial capacity of a Berberis vulgaris plant extract on the bacteria being associated with caries including, Streptococcus mutans, S. sobrinus, S. sanguinis, S. salivaris and Lactobacillus rhamnosus. MATERIAL AND
methodsChlorhexidine 2% (CHX) mouthwash and ampicillin (10 μg/disk) were applied as positive control groups. Inhibition zone, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) related to stem, leaf and fruit of B. vulgaris plant were recorded for every five bacteria. Data were analyzed using SPSS ver. 22, one-way ANOVA repeated measure and post hoc Tukey statistical test. The significance level was set at p < 0.05.
resultsThere were no significant differences between the antimicrobial capacity of the positive controls and the extract from the stem and fruit of B. vulgaris (p > 0.05). The MIC values of the extract from the stem were significantly lower against S. sobrinus (64 μg/ml) and L. rhamnosus (128 μg/ml). The MIC value of the extract against S. mutans was significantly lower in the fruit group (64 μg/mL). The MBC value of the extract against S. sobrinus and L. rhamnosus was significantly lower in the stem group (128 μg/ml). The MBC value against S. mutans was significantly lower in the fruit group (128 μg/ml).
conclusionsThe results showed that CHX and B. vulgaris plant extract have similar antimicrobial activity against bacteria being associated with caries. Therefore, B. vulgaris, which shows antibacterial capacity, could be considered for further investigation as a safe, phytotherapeutic mouthwash to prevent dental caries.
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