Evidence map›Paper›PMID 33324979›Full record

ArticleEuropean heart journal. Cardiovascular Imaging2021

Computed tomography angiography-derived extracellular volume fraction predicts early recovery of left ventricular systolic function after transcatheter aortic valve replacement.

Donghee Han, Balaji Tamarappoo, Eyal Klein, Jeffrey Tyler, Tarun Chakravarty, Yuka Otaki, Robert Miller, Evann Eisenberg, Rebekah Park, Siddharth Singh and 10 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal. Cardiovascular Imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05069168 (Predictors of Left Ventricular Systolic Function Recovery After Transcatheter Aortic Valve), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05069168 completednot on this mapstarted 2023, after this paper: background citation

Predictors of Left Ventricular Systolic Function Recovery After Transcatheter Aortic Valve

TypeobservationalSponsorAssiut UniversityRan2023 to 2024Enrolled75ConditionsLeft Ventricular Systolic FunctionArmsEchocardiography before and after TAVR
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  3. Left ventricular systolic recovery after TAVI in severe aortic stenosis: A systematic review and meta-analysis.International journal of cardiology. Cardiovascular risk and prevention · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 1 institution in 1 country.

Donghee HanMark Taper Imaging Center, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90028, USA.
Balaji TamarappooMark Taper Imaging Center, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90028, USA.
Eyal KleinMark Taper Imaging Center, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90028, USA.
Jeffrey TylerSmidt Heart Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90028, USA.
Tarun ChakravartySmidt Heart Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90028, USA.
Yuka OtakiMark Taper Imaging Center, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90028, USA.
Robert MillerMark Taper Imaging Center, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90028, USA.
Evann EisenbergMark Taper Imaging Center, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90028, USA.
Rebekah ParkMark Taper Imaging Center, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90028, USA.
Siddharth SinghSmidt Heart Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90028, USA.
Takahiro ShiotaSmidt Heart Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90028, USA.
Robert SiegelSmidt Heart Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90028, USA.
Jasminka StegicSmidt Heart Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90028, USA.
Tracy SalsethSmidt Heart Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90028, USA.
Wen ChengSmidt Heart Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90028, USA.
Damini DeyMark Taper Imaging Center, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90028, USA.
Louise ThomsonMark Taper Imaging Center, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90028, USA.
Daniel BermanMark Taper Imaging Center, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90028, USA.
Raj MakkarMark Taper Imaging Center, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90028, USA.
John FriedmanMark Taper Imaging Center, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90028, USA.
Cedars-Sinai Medical Center · US

Funding

Detection of vulnerable atherosclerotic plaque with a novel 18F-labeled Integrin targeted PET imaging agentR56HL131871 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI TAMARAPPOO, BALAJI K. · 2016 to 2016
$496k
NHLBI NIH HHS R56 HL131871
6 · The paper itself

Abstract

aimsRecovery of left ventricular ejection fraction (LVEF) after aortic valve replacement has prognostic importance in patients with aortic stenosis (AS). The mechanism by which myocardial fibrosis impacts LVEF recovery in AS is not well characterized. We sought to evaluate the predictive value of extracellular volume fraction (ECV) quantified by cardiac CT angiography (CTA) for LVEF recovery in patients with AS after transcatheter aortic valve replacement (TAVR). METHODS AND

resultsIn 109 pre-TAVR patients with LVEF <50% at baseline echocardiography, CTA-derived ECV was calculated as the ratio of change in CT attenuation of the myocardium and the left ventricular (LV) blood pool before and after contrast administration. Early LVEF recovery was defined as an absolute increase of ≥10% in LVEF measured by post-TAVR follow-up echocardiography within 6 months of the procedure. Early LVEF recovery was observed in 39 (36%) patients. The absolute increase in LVEF was 17.6 ± 8.8% in the LVEF recovery group and 0.9 ± 5.9% in the no LVEF recovery group (P < 0.001). ECV was significantly lower in patients with LVEF recovery compared with those without LVEF recovery (29.4 ± 6.1% vs. 33.2 ± 7.7%, respectively, P = 0.009). In multivariable analysis, mean pressure gradient across the aortic valve [odds ratio (OR): 1.07, 95% confidence interval (CI): 1.03-1.11, P: 0.001], LV end-diastolic volume (OR: 0.99, 95% CI: 0.98-0.99, P: 0.035), and ECV (OR: 0.92, 95% CI: 0.86-0.99, P: 0.018) were independent predictors of early LVEF recovery.

conclusionIncreased myocardial ECV on CTA is associated with impaired LVEF recovery post-TAVR in severe AS patients with impaired LV systolic function.

Indexed as

Aortic Valve StenosisTranscatheter Aortic Valve ReplacementVentricular Dysfunction, LeftAortic ValveComputed Tomography AngiographyHumansRecovery of FunctionRetrospective StudiesStroke VolumeTreatment OutcomeVentricular Function, Leftaortic stenosiscomputed tomographyextracellular volumeleft ventricular functionmyocardial fibrosistranscatheter aortic valve replacement

Identifiers

PMID33324979
PMCPMC7822636
OpenAlexW3112747434

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.