ReviewFrontiers in veterinary science2020
Prognostic Factors in Canine Acute Intervertebral Disc Disease.
Review in Frontiers in veterinary science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Feline intervertebral disc disease: a systematic review and meta-analysis.Journal of feline medicine and surgery · 2025Pooled it
- Spatiotemporal disarray of inflammatory microenvironment following spinal cord injury.Neural regeneration research · 2026Article
- Computed tomography versus magnetic resonance imaging for the perioperative management of acute thoracolumbar intervertebral disc extrusion in non-ambulatory chondrodystrophic dogs.Veterinary surgery : VS · 2026Article
- Effect of postoperative underwater treadmill therapy on functional recovery in dogs undergoing intervertebral disc surgery: a retrospective matched cohort study.Journal of veterinary internal medicine · 2026Article
- Acute hydrated nucleus pulposus extrusion in dogs with severe neurologic status: comparison between conservative and surgical treatment.Journal of veterinary internal medicine · 2026Article
- Review: spinal shock, crossed extensor reflex, and mass reflex in dogs and cats-a literature review, clinical observations and considerations.Frontiers in veterinary science · 2026Review
- Teaching common cognitive biases and associated errors in veterinary neurologic diagnosis using clinical vignettes: a narrative review.Frontiers in veterinary science · 2026Review
- Chronic sequelae and owner burdens are common following canine intervertebral disc disease.The Veterinary record · 2025Article
- Diagnostic and Prognostic Value of Serum Neurofilament Light Chain in Canine Spinal Cord Diseases.Veterinary sciences · 2025Article
- Machine learning and quantitative computed tomography radiomics prediction of postoperative functional recovery in paraplegic dogs.Veterinary surgery : VS · 2025Article
- Correlation of Mechanical Thresholds, Glasgow Composite Measure Pain Scale, and Sharp and Wheeler Grading Scale in Dogs with Acute Thoracolumbar Disc Extrusions.Animals : an open access journal from MDPI · 2025Article
- Machine-learning-based prediction of functional recovery in deep-pain-negative dogs after decompressive thoracolumbar hemilaminectomy for acute intervertebral disc extrusion.Veterinary surgery : VS · 2025Article
- Mechanisms and Factors Influencing Resorption of Herniated Part of Lumbar Disc Herniation: Comprehensive Review.Journal of inflammation research · 2025Review
- Clinical presentation, magnetic resonance imaging characteristics, and short-term outcome of deep surgical site infection following thoracolumbar decompressive spinal surgery for intervertebral disc herniation in dogs.Frontiers in veterinary science · 2025Article
- A laminin-based therapy for dogs with chronic spinal cord injury: promising results of a longitudinal trial.Frontiers in veterinary science · 2025Article
- Influence of gonadectomy and age at gonadectomy on the risk of developing intervertebral disc herniation in French Bulldogs: a retrospective study.Frontiers in veterinary science · 2025Article
- Article
- On the utility of cerebrospinal fluid biomarkers in canine neurological disorders.Scientific reports · 2024Article
- Physiotherapy in the Recovery of Paraplegic Dogs without Nociception Due to Thoracolumbar Intervertebral Disc Extrusion Treated Surgically.Animals : an open access journal from MDPI · 2024Article
- Exploring deep learning strategies for intervertebral disc herniation detection on veterinary MRI.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Knowledge of the prognosis of acute spinal cord injury is critical to provide appropriate information for clients and make the best treatment choices. Acute intervertebral disc extrusions (IVDE) are a common cause of pain and paralysis in dogs with several types of IVDE occurring. Important prognostic considerations are recovery of ambulation, return of urinary and fecal continence, resolution of pain and, on the negative side, development of progressive myelomalacia. Initial injury severity affects prognosis as does type of IVDE, particularly when considering recovery of continence. Overall, loss of deep pain perception signals a worse outcome. When considering Hansen type 1 IVDE, the prognosis is altered by the choice of surgical vs. medical therapy. Concentration of structural proteins in the plasma, as well as inflammatory mediators, creatine kinase, and myelin basic protein in the cerebrospinal fluid (CSF) can provide additional prognostic information. Finally, cross-sectional area and length of T2 hyperintensity and loss of HASTE signal on MRI have been associated with outcome. Future developments in plasma and imaging biomarkers will assist in accurate prognostication and optimization of patient management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.