Evidence map›Paper›PMID 33324552›Full record

ArticleFrontiers in oncology2020

PROTAC Bromodomain Inhibitor ARV-825 Displays Anti-Tumor Activity in Neuroblastoma by Repressing Expression of

Zhiheng Li, Su Lin Lim, Yanfang Tao, Xiaolu Li, Yi Xie, Chun Yang, Zimu Zhang, You Jiang, Xianbing Zhang, Xu Cao and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 38 citations in OpenAlex.

  1. Generalizable Strategies for the Synthesis of Cereblon-Recruiting PROTAC Prodrugs.Angewandte Chemie (International ed. in English) · 2026
    Article
  2. Review
  3. Targeting MYC-Driven Cancers: From Oncogenic Addiction to Therapeutic Vulnerability.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Viability ofmicroPublication biology · 2026
    Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Molecular regulation and therapeutic targeting ofFrontiers in cell and developmental biology · 2025
    Review
  16. Advances of E3 ligases in lung cancer.Biochemistry and biophysics reports · 2024
    Review
  17. Review
  18. Review
  19. Epigenetic Dysregulation inInternational journal of molecular sciences · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 4 institutions in 2 countries.

Zhiheng LiInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, China.
Su Lin LimDepartment of Internal Medicine, Saint Michael's Medical Center, Newark, NJ, United States.
Yanfang TaoInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, China.
Xiaolu LiInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, China.
Yi XieInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, China.
Chun YangInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, China.
Zimu ZhangInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, China.
You JiangDepartment of Hematology, Children's Hospital of Soochow University, Suzhou, China.
Xianbing ZhangDepartment of Pediatric Surgery, The First People's Hospital of Kunshan, Suzhou, China.
Xu CaoDepartment of Pediatric Surgery, Children's Hospital of Soochow University, Suzhou, China.
Hairong WangInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, China.
Guanghui QianInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, China.
Yi WuDepartment of Pathology, Children's Hospital of Soochow University, Suzhou, China.
Mei LiInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, China.
Fang FangInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, China.
Ying LiuInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, China.
Mingcui FuDepartment of Pediatric Surgery, Children's Hospital of Soochow University, Suzhou, China.
Xin DingDepartment of Neonatology, Children's Hospital of Soochow University, Suzhou, China.
Zhenghong ZhuDepartment of Burn and Plastic Surgery, Children's Hospital of Soochow University, Suzhou, China.
Haitao LvDepartment of Cardiology, Children's Hospital of Soochow University, Suzhou, China.
Jun LuDepartment of Hematology, Children's Hospital of Soochow University, Suzhou, China.
Sheng XiaoDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Shaoyan HuInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, China.
Jian PanInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, China.
Soochow University · CNBrigham and Women's Hospital · USJiangsu University · CNSaint Michael's Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroblastoma (NB) is one of the most common solid tumors in childhood. To date, targeting

Indexed as

ARV-825BRD4c-MycMYCNneuroblastoma

Identifiers

PMID33324552
PMCPMC7726414
OpenAlexW3108222024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.