ArticleCureus2020
Spontaneous Spinal Epidural Hematoma Associated With Apixaban Therapy: A Report of two Cases.
Article in Cureus, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- Spontaneous Spinal Epidural Haematoma Associated With Direct Oral Anticoagulants: A Descriptive Systematic Review.Cureus · 2026Review
- Pharmacovigilance study of spinal epidural hematoma reports associated with direct oral anticoagulants and warfarin.Acta neurochirurgica · 2026Article
- Chronic Expanding Hematoma in the Upper Extremity: A Case Report on Diagnostic and Management Challenges.Cureus · 2024Article
- A rare case of non-traumatic spinal epidural hematoma in lumbar region associated with apixaban therapy.Journal of thrombosis and thrombolysis · 2021Article
- Spontaneous thoracolumbar epidural hematoma in an apixaban anticoagulated patient.Surgical neurology international · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spontaneous spinal epidural hematoma (SSEH) is a rare clinical entity that can result in severe neurological deficit and warrants emergent neurosurgical evaluation and management. The exact etiology of this entity remains unknown, but certain risk factors exist, including the use of anticoagulant medications. There are few published reports of the association of SSEH with direct factor Xa inhibitors. We aimed to present 2 cases of SSEH in patients on chronic apixaban therapy. To the best of our knowledge, there is only 1 other report of SSEH in the setting of apixaban therapy. A comparison between the cases suggests the importance of rapid recognition and management of SSEH in order to achieve favorable neurological outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.