Evidence map›Paper›PMID 33324421›Full record

ReviewFrontiers in immunology2020

Phenotyping of Adaptive Immune Responses in Inflammatory Diseases.

Jens Y Humrich, Joana P Bernardes, Ralf J Ludwig, David Klatzmann, Alexander Scheffold

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Cancer risk and mortality assessment in the overweight population: evaluation of single and integrated models based on inflammatory markers.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  2. Editorial: Autoimmune pre-disease.Frontiers in immunology · 2023
    Article
  3. Review
  4. Lichen Planus.Frontiers in medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Jens Y HumrichDepartment of Rheumatology and Clinical Immunology, University Hospital Schleswig-Holstein-Campus Lübeck, Lübeck, Germany.
Joana P BernardesInstitute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Kiel, Germany.
Ralf J LudwigLübeck Institute of Experimental Dermatology (LIED), University of Lübeck, Lübeck, Germany.
David KlatzmannSorbonne Université, INSERM, Immunology-Immunopathology-Immunotherapy (i3), Paris, France.
Alexander ScheffoldInstitute of Immunology, Christian-Albrechts-University Kiel, Kiel, Germany.
Christian-Albrechts-Universität zu Kiel · DEInserm · FRUniversity Medical Center · USUniversity of Lübeck · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunophenotyping on the molecular and cellular level is a central aspect for characterization of patients with inflammatory diseases, both to better understand disease etiopathogenesis and based on this to develop diagnostic and prognostic biomarkers which allow patient stratification and tailor-made treatment strategies. Technology-driven developments have considerably expanded the range of analysis tools. Especially the analysis of adaptive immune responses, often regarded as central though mostly poorly characterized disease drivers, is a major focus of personalized medicine. The identification of the disease-relevant antigens and characterization of corresponding antigen-specific lymphocytes in individual patients benefits significantly from recent developments in cytometry by sequencing and proteomics. The aim of this workshop was to identify the important developments for state-of-the-art immunophenotyping for clinical application and precision medicine. We focused here on recent key developments in analysis of antigen-specific lymphocytes, sequencing, and proteomics approaches, their relevance in precision medicine and the discussion of the major challenges and opportunities for the future.

Indexed as

Adaptive ImmunityAnimalsB-LymphocytesCongresses as TopicHigh-Throughput Nucleotide SequencingHumansImmunophenotypingInflammationPhenotypeProteomicsReceptors, Antigen, T-CellT-LymphocytesReceptors, Antigen, T-Cellantigensimmunophenotypinginflammationprecision medicineproteomicssequencingTCR repertoire

Identifiers

PMID33324421
PMCPMC7723922
OpenAlexW3109320617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.