ArticleFrontiers in immunology2020
Accurate and Efficient KIR Gene and Haplotype Inference From Genome Sequencing Reads With Novel K-mer Signatures.
Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- High KIR diversity in Uganda and Botswana children living with HIV.Human immunology · 2026Article
- VN1K is a pangenome-informed multi-omics and phenomics resource for the Vietnamese population.Nature communications · 2026Article
- Graph-KIR: graph-based KIR copy number estimation and allele calling using short-read sequencing data.Bioinformatics (Oxford, England) · 2026Article
- Geny: a genotyping tool for allelic decomposition of killer cell immunoglobulin-like receptor genes.Frontiers in immunology · 2024Article
- Efficient and accurate KIR and HLA genotyping with massively parallel sequencing data.Genome research · 2023Article
- ERAP/HLA-C and KIR Genetic Profile in Couples with Recurrent Implantation Failure.International journal of molecular sciences · 2022Article
- Decoding the diversity of killer immunoglobulin-like receptors by deep sequencing and a high-resolution imputation method.Cell genomics · 2022Article
- KIR gene content imputation from single-nucleotide polymorphisms in the Finnish population.PeerJ · 2022Article
- Killer Cell Immunoglobulin-Like Receptor Haplotype B Modulates Susceptibility to EBV-Associated Classic Hodgkin Lymphoma.Frontiers in immunology · 2022Article
- Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01.EClinicalMedicine · 2021Article
- HIV-1 and human genetic variation.Nature reviews. Genetics · 2021Review
- High-throughput Interpretation of Killer-cell Immunoglobulin-like Receptor Short-read Sequencing Data with PING.PLoS computational biology · 2021Article
- Demonstrating the utility of flexible sequence queries against indexed short reads with FlexTyper.PLoS computational biology · 2021Article
- Efficient Sequencing, Assembly, and Annotation of Human KIR Haplotypes.Frontiers in immunology · 2020Article
- Accurate and Efficient KIR Gene and Haplotype Inference From Genome Sequencing Reads With Novel K-mer Signatures.Frontiers in immunology · 2020Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The killer-cell immunoglobulin-like receptor (KIR) proteins evolve to fight viruses and mediate the body's reaction to pregnancy. These roles provide selection pressure for variation at both the structural/haplotype and base/allele levels. At the same time, the genes have evolved relatively recently by tandem duplication and therefore exhibit very high sequence similarity over thousands of bases. These variation-homology patterns make it impossible to interpret KIR haplotypes from abundant short-read genome sequencing data at population scale using existing methods. Here, we developed an efficient computational approach for
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