Evidence map›Paper›PMID 33324377›Full record

ArticleFrontiers in microbiology2020

High Levels of Within-Host Variations of Human Papillomavirus 16

Yusuke Hirose, Mayuko Yamaguchi-Naka, Mamiko Onuki, Yuri Tenjimbayashi, Nobutaka Tasaka, Toyomi Satoh, Kohsei Tanaka, Takashi Iwata, Akihiko Sekizawa, Koji Matsumoto and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Bacterial DNA involvement in carcinogenesis.Frontiers in cellular and infection microbiology · 2022
    Review
  8. Role of HPV16 E1 in cervical carcinogenesis.Frontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Yusuke HiroseDepartment of Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan.
Mayuko Yamaguchi-NakaDepartment of Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan.
Mamiko OnukiDepartment of Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan.
Yuri TenjimbayashiDepartment of Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan.
Nobutaka TasakaDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Toyomi SatohDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Kohsei TanakaPathogen Genomics Center, National Institute of Infectious Diseases, Tokyo, Japan.
Takashi IwataDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Akihiko SekizawaDepartment of Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan.
Koji MatsumotoDepartment of Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan.
Iwao KukimotoPathogen Genomics Center, National Institute of Infectious Diseases, Tokyo, Japan.
Showa University · JPKeio University · JPUniversity of Tsukuba · JPNational Institute of Infectious Diseases · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human papillomavirus type 16 (HPV16) is the most common HPV genotype found in invasive cervical cancer (ICC). Recent comprehensive genomics studies of HPV16 have revealed that a large number of minor nucleotide variations in the viral genome are present in each infected woman; however, it remains unclear whether such within-host variations of HPV16 are linked to cervical carcinogenesis. Here, by employing next-generation sequencing approaches, we explored the mutational profiles of the HPV16 genome within individual clinical specimens from ICC (

Indexed as

APOBECE1/E2human papillomaviruspositive selectionwithin-host variation

Identifiers

PMID33324377
PMCPMC7721666
OpenAlexW3109425975

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.