Evidence map›Paper›PMID 33324037›Full record

ArticleDrug design, development and therapy2020

The Skeletal Effects of Short-Term Triple Therapy in a Rat Model of Gastric Ulcer Induced by

Sophia Ogechi Ekeuku, Benjamin Ka Seng Thong, Adam Quraisiah, Fazalda Annuar, Alfizah Hanafiah, Mohd Fahami Nur Azlina, Kok-Yong Chin

Abstract read
In one paragraph

Article in Drug design, development and therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Particulate Air Pollution and Osteoporosis: A Systematic Review.Risk management and healthcare policy · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sophia Ogechi EkeukuDepartment of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Malaysia.ORCID 0000-0002-5485-4592
Benjamin Ka Seng ThongDepartment of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Malaysia.ORCID 0000-0003-1096-6936
Adam QuraisiahDepartment of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Malaysia.ORCID 0000-0002-1689-290X
Fazalda AnnuarDepartment of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Malaysia.ORCID 0000-0002-9846-9282
Alfizah HanafiahDepartment of Medical Microbiology & Immunology Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Malaysia.ORCID 0000-0003-4859-1439
Mohd Fahami Nur AzlinaDepartment of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Malaysia.
Kok-Yong ChinDepartment of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Malaysia.ORCID 0000-0001-6628-1552

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTriple therapy is the standard therapy to eradicate

methodsThree-month-old male Sprague Dawley rats were assigned to normal control,

resultsBone mineral content was significantly lower in the negative control group compared to the triple therapy group (p=0.014). Triple therapy decreased strain (vs negative control, p=0.002) and displacement of the femur (vs normal control, p=0.004; vs untreated control, p=0.005). No significant difference was observed in other parameters among the study groups (p>0.05).

conclusionShort-term triple therapy increases bone mineral content but decreases bone strength of rats. Skeletal prophylaxis should be considered for patients on short-term triple therapy containing PPI.

Indexed as

AnimalsAnti-Bacterial AgentsAnti-Ulcer AgentsBone and BonesDrug Therapy, CombinationHelicobacter InfectionsHelicobacter pyloriMaleRatsRats, Sprague-DawleyAnti-Bacterial AgentsAnti-Ulcer Agentsbonegastric ulceromeprazoleosteopeniaosteoporosisproton pump inhibitor

Identifiers

PMID33324037
PMCPMC7732759

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.