Evidence map›Paper›PMID 33323547›Full record

ArticleAging2020

Silencing LINC00482 inhibits tumor-associated inflammation and angiogenesis through down-regulation of MMP-15

Yizhuo Wang, Liping Zhang, Na Wei, Yue Sun, Weiyun Pan, Yan Chen

Open access · greenAbstract read
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 34 citations in OpenAlex.

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  13. An Overview of Angiogenesis in Bladder Cancer.Current oncology reports · 2023
    Review
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  20. PBX1: a key character of the hallmarks of cancer.Journal of molecular medicine (Berlin, Germany) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yizhuo WangCancer Center, The First Hospital of Jilin University, Changchun 130021, P. R. China.
Liping ZhangDepartment of Cardiology, The First Hospital of Jilin University, Changchun 130021, P. R. China.
Na WeiThe First Operating Room, The First Hospital of Jilin University, Changchun 130021, P. R. China.
Yue SunThe First Operating Room, The First Hospital of Jilin University, Changchun 130021, P. R. China.
Weiyun PanDepartment of Intensive Care Unit (ICU), The First Hospital of Jilin University, Changchun 130021, P. R. China.
Yan ChenDepartment of Gastrointestinal Surgery, The First Hospital of Jilin University, Changchun 130021, P. R. China.
First Hospital of Jilin University · CNJilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple studies have previously demonstrated that long intergenic non-coding RNAs (lincRNAs) play an important role in the development of bladder cancer. However, little is known regarding the underlying molecular mechanisms of LINC00482 functions in bladder cancer. The current study aimed to elucidate the role of LINC00482 in the progression of bladder cancer. The initial step was to detect the expressions of LINC00482 and MMP15 in bladder cancer cells and tissue. According to the results from the RT-qPCR, LINC00482 and MMP15 were both highly expressed in bladder cancer cells and tissue. The relationship among LINC00482, FOXA1 and MMP15 was studied

Indexed as

Gene SilencingAgedAnimalsCell Line, TumorComputational BiologyDown-RegulationFemaleGene Expression Regulation, NeoplasticHepatocyte Nuclear Factor 3-alphaHumansMaleMatrix Metalloproteinase 15MiceMice, Inbred BALB CMiddle AgedNeovascularization, PathologicFOXA1 protein, humanHepatocyte Nuclear Factor 3-alphaMatrix Metalloproteinase 15MMP15 protein, humanNF-kappa BRNA, Long NoncodingVascular Endothelial Growth Factor Abladder cancerFOXA1inflammationLINC00482MMP15

Identifiers

PMID33323547
PMCPMC7880329
OpenAlexW3112486355

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.