ArticleAging2020
Mendelian randomization study of telomere length and bone mineral density.
Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- A genomic structural equation modelling analysis of the shared genetic architecture of the aging spine.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Seipin as a Putative Protective Factor for Breast Cancer: Evidence from Mendelian Randomization Analysis.International journal of women's health · 2026Article
- Exploring the mediating role of telomere length in the association between physical activity and bone mineral density.Aging clinical and experimental research · 2025Article
- Relationship between bullous pemphigoid and malignancy: A Mendelian randomization study.The Journal of dermatology · 2024Article
- Frailty and risk of systemic atherosclerosis: A bidirectional Mendelian randomization study.PloS one · 2024Article
- Osteoporosis and osteoarthritis: a bi-directional Mendelian randomization study.Arthritis research & therapy · 2023Article
- Causal association of epigenetic aging and osteoporosis: a bidirectional Mendelian randomization study.BMC medical genomics · 2023Article
- Irritability and risk of lung cancer: a Mendelian randomization and mediation analysis.Journal of cancer research and clinical oncology · 2023Article
- The Causal Association Between Obesity and Primary Open-Angle Glaucoma: A Two-Sample Mendelian Randomization Study.Frontiers in genetics · 2022Article
- Genetic Predisposition to Severe COVID-19 Might Increase the Risk of Stroke: A Two-Sample Mendelian Randomization Study.Frontiers in genetics · 2022Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSome epidemiological studies and animal studies have reported a relationship between leukocyte telomere length (LTL) and bone mineral density (BMD). However, the causality underlying the purported relationship has not been determined. Here we performed a two-sample MR analysis to test the causal link between telomere length and BMD.
resultsOur research suggested no causal link of LTL and BMD using IVW method. The weighted median, MR-Egger regression and MR.RAPS method yielded a similar pattern of effects. MR-Egger intercept test demonstrated our results were not influenced by pleiotropy. Heterogeneities among the genetic variants on heel estimated BMD and TB-BMD vanished after excluding rs6028466. "Leave-one-out" sensitivity analysis confirmed the stability of our results.
conclusionOur MR analysis did not support causal effect of telomere length on BMD.
methodsWe utilized 5 independent SNPs robustly associated with LTL as instrument variables. The outcome results were obtained from GWAS summary data of BMD. The two-sample MR analysis was conducted using IVW, weighted median, MR-Egger regression and MR.RAPS method. MR-Egger intercept test, Cochran's Q test and I
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.