Evidence map›Paper›PMID 33323543›Full record

ArticleAging2020

Screening and functional prediction of differentially expressed circular RNAs in human glioma of different grades.

Xiuchao Geng, Yuhao Zhang, Qiang Li, Wang Xi, Wentao Yu, Liang Shi, Xiaomeng Lin, Shaoguang Sun, Hong Wang

Open access · greenAbstract read
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. NMolecular neurobiology · 2026
    Article
  3. Role of non-coding RNAs in OOncology letters · 2026
    Review
  4. CircFBXW4 Suppresses Colorectal Cancer Progression by Regulating the MiR-338-5p/SLC5A7 Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Molecular mechanism of mCell death discovery · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Xiuchao GengFaculty of Integrated Traditional Chinese and Western Medicine, Hebei University of Chinese Medicine, Shijiazhuang 050091, PR China.
Yuhao ZhangSchool of Clinical Medicine, Hebei University, Baoding 071000, PR China.
Qiang LiFaculty of Acupuncture-Moxibustion and Tuina, Hebei University of Chinese Medicine, Shijiazhuang 050200, PR China.
Wang XiDepartment of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, PR China.
Wentao YuFaculty of Acupuncture-Moxibustion and Tuina, Hebei University of Chinese Medicine, Shijiazhuang 050200, PR China.
Liang ShiEndoscope Room, Department of General Surgery, Cangzhou Central Hospital, Cangzhou 061001, PR China.
Xiaomeng LinDepartments of Breast Surgery, Affiliated Hospital of Hebei University, Baoding 071000, PR China.
Shaoguang SunDepartment of Biochemistry and Molecular Biology, Key Laboratory of Medical Biotechnology of Hebei Province, Hebei Medical University, Shijiazhuang 050017, PR China.
Hong WangFaculty of Integrated Traditional Chinese and Western Medicine, Hebei University of Chinese Medicine, Shijiazhuang 050091, PR China.
Hebei University of Chinese Medicine · CNHebei Medical University · CNAffiliated Hospital of Hebei University · CNCangzhou Central Hospital · CNHebei University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNAs (circRNAs) have a critical regulatory function in human glioma. However, novel circRNAs related to different pathological grades of glioma and their crucial potential function are worth screening and prediction. CircRNA expression profiling was performed for 6 paired high- and low-grade glioma tissues and 5 adjacent normal brain tissues through next-generation sequencing. Quantitative real-time PCR (qRT-PCR) was conducted to validate circRNA expression. Bioinformatics analysis was performed, and circRNA-miRNA-mRNA networks were constructed. The expression and survival data of miRNAs and target genes were examined by GEPIA, Chinese Glioma Genome Atlas (CGGA), ONCOMINE, and cBioPortal databases. The RNA binding proteins (RBPs), open reading frames (ORFs) and N6-methyladenosine (m

Indexed as

AdenosineAdultAgedBrain ChemistryBrain NeoplasmsComputational BiologyFemaleGene Regulatory NetworksGliomaHigh-Throughput Nucleotide SequencingHumansMaleMass ScreeningMetabolic Networks and PathwaysMiddle AgedNeoplasm GradingAdenosineN-methyladenosineRNA, CircularcircRNAfunctional predictiongliomaRNA sequencing

Identifiers

PMID33323543
PMCPMC7880344
OpenAlexW3112181740

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.