Evidence map›Paper›PMID 33323516›Full record

ArticlemBio2020

A Noncanonical DNA Damage Checkpoint Response in a Major Fungal Pathogen.

Erika Shor, Rocio Garcia-Rubio, Lucius DeGregorio, David S Perlin

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. bioRxiv : the preprint server for biology · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. The putative error prone polymerasenpj antimicrobials and resistance · 2024
    Article
  10. Article
  11. Article
  12. CryptoCEN: A Co-Expression Network forbioRxiv : the preprint server for biology · 2023
    Article
  13. UsingVirulence · 2022
    Article
  14. Transcriptional Profiling of theInternational journal of molecular sciences · 2022
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. DNA damage checkpoint and repair: From the budding yeastComputational and structural biotechnology journal · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Erika ShorCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA erika.shor@hmh-cdi.org david.perlin@hmh-cdi.org.ORCID 0000-0003-3655-0963
Rocio Garcia-RubioCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Lucius DeGregorioCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
David S PerlinCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA erika.shor@hmh-cdi.org david.perlin@hmh-cdi.org.ORCID 0000-0002-1268-5524
Hackensack Meridian Health · USGeorgetown University · US

Funding

Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI Louis M Weiner · 1990 to 2026
$71.5M
Critical Factors Influencing Echinocandin Resistance in CandidaglabrataR01AI109025 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI PERLIN, DAVID S · 2014 to 2025
$9.8M
NCI NIH HHS P30 CA051008NIAID NIH HHS R01 AI109025
6 · The paper itself

Abstract

DNA damage checkpoints are key guardians of genome integrity. Eukaryotic cells respond to DNA damage by triggering extensive phosphorylation of Rad53/CHK2 effector kinase, whereupon activated Rad53/CHK2 mediates further aspects of checkpoint activation, including cell cycle arrest and transcriptional changes. Budding yeast

Indexed as

Cell Cycle CheckpointsDNA DamageCell DivisionCheckpoint Kinase 2Fungal ProteinsGene Expression Regulation, FungalHumansMycosesPhosphorylationSaccharomyces cerevisiaeSaccharomycetalesS PhaseCheckpoint Kinase 2Fungal ProteinsCandida glabratacell divisionDNA damage checkpointsDNA damage responseRad53

Identifiers

PMID33323516
PMCPMC7773997
OpenAlexW3112854643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.