Evidence map›Paper›PMID 33323456›Full record

ArticleMolecular cancer therapeutics2021

Neutralization of TGFβ Improves Tumor Immunity and Reduces Tumor Progression in Ovarian Carcinoma.

Brandon M Roane, Selene Meza-Perez, Ashwini A Katre, Whitney N Goldsberry, Troy D Randall, Lyse A Norian, Michael J Birrer, Rebecca C Arend

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Brandon M RoaneDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0002-3234-9851
Selene Meza-PerezDivision of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Ashwini A KatreDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama.
Whitney N GoldsberryDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama.
Troy D RandallDivision of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Lyse A NorianComprehensive Cancer Center, University of Alabama at Birmingham, Alabama.ORCID 0000-0003-1016-313X
Michael J BirrerWinthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Rebecca C ArendDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama. rarend@uabmc.edu.ORCID 0000-0003-2108-3426
University of Alabama at Birmingham · USUniversity of Arkansas for Medical Sciences · US

Funding

Role of microbiota in therapy to ovarian cancerR01CA216234 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RANDALL, TROY D · 2017 to 2021
$2.1M
NCI NIH HHS L30 CA209715NCI NIH HHS R01 CA216234
6 · The paper itself

Abstract

The immunosuppressive effects of TGFβ promotes tumor progression and diminishes response to therapy. In this study, we used ID8-p53

Indexed as

AnimalsCell Line, TumorDisease Models, AnimalDisease ProgressionFemaleHumansMiceOvarian NeoplasmsSurvival AnalysisTransfectionTransforming Growth Factor betaTransforming Growth Factor beta

Identifiers

PMID33323456
PMCPMC7933076
OpenAlexW3112900781

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.