Evidence map›Paper›PMID 33323408›Full record

ArticleCancer research2020

Dissecting the Functional Significance of DNA Polymerase Mutations in Cancer.

Amy J Wisdom, David G Kirsch

Open access · bronzeAbstract readComment
In one paragraph

Article in Cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Amy J WisdomDepartment of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina.ORCID 0000-0002-6098-5353
David G KirschDepartment of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina. david.kirsch@duke.edu.ORCID 0000-0002-2086-205X
Duke University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2M
Advancing Cancer Therapy through Ground Breaking Research in Radiation BiologyR35CA197616 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI David Guy Kirsch · 2016 to 2026
$10.7M
Dissecting the role of the immune system in the radiation response of Kras-mutant tumorsF30CA221268 · NCI · DUKE UNIVERSITY · PI WISDOM, AMY JORDAN · 2017 to 2020
$154k
NCI NIH HHS F30 CA221268NCI NIH HHS R35 CA197616NIGMS NIH HHS T32 GM007171
6 · The paper itself

Abstract

DNA polymerase mutations can cause hypermutant cancers, but the mechanisms of tumorigenesis and the impact of various DNA polymerase mutations on treatment response is poorly understood. In this issue of

Indexed as

Immune Checkpoint InhibitorsNeoplasmsAnimalsDNA Polymerase IIImmunotherapyMiceMutationTumor MicroenvironmentDNA Polymerase IIImmune Checkpoint Inhibitors

Identifiers

PMID33323408
PMCPMC7931142
OpenAlexW3111530880

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.