Evidence map›Paper›PMID 33323380›Full record

ArticleCancer research2021

A Very Long-Acting PARP Inhibitor Suppresses Cancer Cell Growth in DNA Repair-Deficient Tumor Models.

Shaun D Fontaine, Gary W Ashley, Peter J Houghton, Raushan T Kurmasheva, Morgan Diolaiti, Alan Ashworth, Cody J Peer, Ryan Nguyen, William D Figg, Denis R Beckford-Vera and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Shaun D FontaineProLynx, San Francisco, California.ORCID https://orcid.org/0000-0002-5800-0391
Gary W AshleyProLynx, San Francisco, California.
Peter J HoughtonGreehey Children's Cancer Research Institute, UT Health San Antonio, Texas.
Raushan T KurmashevaGreehey Children's Cancer Research Institute, UT Health San Antonio, Texas.ORCID https://orcid.org/0000-0003-3212-2363
Morgan DiolaitiUCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California.
Alan AshworthUCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California.
Cody J PeerPharmacology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.ORCID https://orcid.org/0000-0001-9395-3473
Ryan NguyenPharmacology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.ORCID https://orcid.org/0000-0003-0953-7536
William D FiggPharmacology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Denis R Beckford-VeraDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Daniel V SantiProLynx, San Francisco, California. daniel.v.santi@prolynxinc.com.
Dynavax Technologies (United States) · USNational Cancer Institute · USChildren's Cancer Center · USUCSF Helen Diller Family Comprehensive Cancer Center · USUniversity of California, San Francisco · US

Funding

Using Clinical Pharmacology Principles to Develop New Anticancer TherapiesZICSC006537 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI FIGG, WILLIAM DOUGLAS · 2009 to 2025
$14.4M
Pediatric Preclinical Testing Consortium: Research Programs Non-CNS (U01)U01CA199297 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HOUGHTON, PETER J · 2015 to 2021
$3.5M
A Testing Program to Identify Novel Agents for Treatment of Pediatric and AYA High-Risk Sarcoma, Kidney and Liver CancerU01CA263981 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Raushan Kurmasheva · 2021 to 2026
$3.2M
NCI NIH HHS U01 CA199297NCI NIH HHS U01 CA263981
6 · The paper itself

Abstract

PARP inhibitors are approved for treatment of cancers with

Indexed as

AnimalsAntineoplastic AgentsCell Line, TumorDelayed-Action PreparationsDNA RepairDNA Repair-Deficiency DisordersFemaleGenes, BRCA2Genes, Wilms TumorHumansMaleMiceMice, Inbred C57BLMice, KnockoutMice, NudeMice, SCIDAntineoplastic AgentsDelayed-Action PreparationsPhthalazinesPoly(ADP-ribose) Polymerase InhibitorsPolyethylene GlycolsProdrugstalazoparibZirconium

Identifiers

PMID33323380
PMCPMC8670222
OpenAlexW3111042827

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.