Evidence map›Paper›PMID 33323116›Full record

ReviewBMC medicine2020

Shaping a data-driven era in dementia care pathway through computational neurology approaches.

KongFatt Wong-Lin, Paula L McClean, Niamh McCombe, Daman Kaur, Jose M Sanchez-Bornot, Paddy Gillespie, Stephen Todd, David P Finn, Alok Joshi, Joseph Kane and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in BMC medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  13. Alzheimer's Disease Assessments Optimized for Diagnostic Accuracy and Administration Time.IEEE journal of translational engineering in health and medicine · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

KongFatt Wong-LinIntelligent Systems Research Centre, School of Computing, Engineering and Intelligent Systems, Ulster University, Magee Campus, Londonderry, Northern Ireland, UK. k.wong-lin@ulster.ac.uk.ORCID 0000-0001-8724-4398
Paula L McCleanNorthern Ireland Centre for Stratified Medicine, Biomedical Sciences Research Institute, Ulster University, Magee Campus, Londonderry, Northern Ireland, UK.
Niamh McCombeIntelligent Systems Research Centre, School of Computing, Engineering and Intelligent Systems, Ulster University, Magee Campus, Londonderry, Northern Ireland, UK.
Daman KaurNorthern Ireland Centre for Stratified Medicine, Biomedical Sciences Research Institute, Ulster University, Magee Campus, Londonderry, Northern Ireland, UK.
Jose M Sanchez-BornotIntelligent Systems Research Centre, School of Computing, Engineering and Intelligent Systems, Ulster University, Magee Campus, Londonderry, Northern Ireland, UK.
Paddy GillespieHealth Economics and Policy Analysis Centre, Discipline of Economics, National University of Ireland, Galway, Ireland.
Stephen ToddAltnagelvin Area Hospital, Western Health and Social Care Trust, Londonderry, Northern Ireland, UK.
David P FinnPharmacology and Therapeutics, School of Medicine, Galway Neuroscience Centre, National University of Ireland, Galway, Ireland.
Alok JoshiIntelligent Systems Research Centre, School of Computing, Engineering and Intelligent Systems, Ulster University, Magee Campus, Londonderry, Northern Ireland, UK.
Joseph KaneSchool of Medicine, Dentistry and Biomedical Sciences, Institute for Health Sciences, Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland, UK.
Bernadette McGuinnessSchool of Medicine, Dentistry and Biomedical Sciences, Institute for Health Sciences, Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland, UK.
University of Ulster · GBQueen's University Belfast · GBNational University of Ireland · IEOllscoil na Gaillimhe – University of Galway · IE

Funding

Interreg Special EU Programmes Body (SEUPB; Centre for Personalised Medicine, IVA 5036)Northern Ireland Functional Brain Mapping Project Facility 1303/101154803Ulster University Research Challenge Fund
6 · The paper itself

Abstract

backgroundDementia is caused by a variety of neurodegenerative diseases and is associated with a decline in memory and other cognitive abilities, while inflicting an enormous socioeconomic burden. The complexity of dementia and its associated comorbidities presents immense challenges for dementia research and care, particularly in clinical decision-making. MAIN BODY: Despite the lack of disease-modifying therapies, there is an increasing and urgent need to make timely and accurate clinical decisions in dementia diagnosis and prognosis to allow appropriate care and treatment. However, the dementia care pathway is currently suboptimal. We propose that through computational approaches, understanding of dementia aetiology could be improved, and dementia assessments could be more standardised, objective and efficient. In particular, we suggest that these will involve appropriate data infrastructure, the use of data-driven computational neurology approaches and the development of practical clinical decision support systems. We also discuss the technical, structural, economic, political and policy-making challenges that accompany such implementations.

conclusionThe data-driven era for dementia research has arrived with the potential to transform the healthcare system, creating a more efficient, transparent and personalised service for dementia.

Indexed as

Critical PathwaysBig DataComorbidityComputational BiologyDatabases, FactualData ScienceDementiaHumansNeurologyAlzheimer’s diseaseClinical decision support systemsComputational modellingComputational neurologyComputational neuroscienceData scienceDementiaDementia care pathwayHealthcare economics

Identifiers

PMID33323116
PMCPMC7738245
OpenAlexW3104107797

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.