ArticleMolecules (Basel, Switzerland)2020
New Multifunctional Agents Based on Conjugates of 4-Amino-2,3-polymethylenequinoline and Butylated Hydroxytoluene for Alzheimer's Disease Treatment.
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Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17citing papers in PubMed
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Who cites it
17 citing papers in PubMed.
- Influence of N-Functionalization of Amiridine on the Biological Activity of Its Conjugates as Multitarget Agents for Potential Treatment of Alzheimer's Disease.ChemMedChem · 2026Article
- Structure-Based Design of New Series of Sulfonates with Potent and Specific BChE Inhibition and Anti-Inflammatory Effects.International journal of molecular sciences · 2026Article
- 1-Azinyl-1'-Alkenylferrocenes with Anticholinesterase, Antioxidant, and Antiaggregating Activities as Multifunctional Agents for Potential Treatment of Alzheimer's Disease.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Advances in isoxazole chemistry and their role in drug discovery.RSC advances · 2025Review
- Conjugates of amiridine and salicylic derivatives as promising multifunctional CNS agents for potential treatment of Alzheimer's disease.Archiv der Pharmazie · 2025Article
- Combining Experimental and Computational Methods to Produce Conjugates of Anticholinesterase and Antioxidant Pharmacophores with Linker Chemistries Affecting Biological Activities Related to Treatment of Alzheimer's Disease.Molecules (Basel, Switzerland) · 2024Article
- Recent Advancements in the Treatment of Alzheimer's Disease: A Multitarget-directed Ligand Approach.Current medicinal chemistry · 2024Review
- Plant-Based Nutraceutical Formulation Modulates the Human Gut Microbiota and Ferulic Acid Esterase Activity During In Vitro Fermentation.Current microbiology · 2023Article
- Conjugates of Tacrine and Salicylic Acid Derivatives as New Promising Multitarget Agents for Alzheimer's Disease.International journal of molecular sciences · 2023Article
- Derivatives of 9-phosphorylated acridine as butyrylcholinesterase inhibitors with antioxidant activity and the ability to inhibit β-amyloid self-aggregation: potential therapeutic agents for Alzheimer's disease.Frontiers in pharmacology · 2023Article
- Powerful Potential of Polyfluoroalkyl-Containing 4-Arylhydrazinylidenepyrazol-3-ones for Pharmaceuticals.Molecules (Basel, Switzerland) · 2022Article
- Conjugates of Methylene Blue with Cycloalkaneindoles as New Multifunctional Agents for Potential Treatment of Neurodegenerative Disease.International journal of molecular sciences · 2022Article
- Synthesis of 4-Aminopyrazol-5-ols as Edaravone Analogs and Their Antioxidant Activity.Molecules (Basel, Switzerland) · 2022Article
- New Multifunctional Agents for Potential Alzheimer's Disease Treatment Based on Tacrine Conjugates with 2-Arylhydrazinylidene-1,3-Diketones.Biomolecules · 2022Article
- Conjugates of Tacrine with Salicylamide as Promising Multitarget Agents for Alzheimer's Disease.ChemMedChem · 2022Article
- Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors:Molecules (Basel, Switzerland) · 2022Article
- Amaryllidaceae Alkaloids of Norbelladine-Type as Inspiration for Development of Highly Selective Butyrylcholinesterase Inhibitors: Synthesis, Biological Activity Evaluation, and Docking Studies.International journal of molecular sciences · 2021Article
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Authors and funding
15 authors.
Galina F MakhaevaInstitute of Physiologically Active Compounds Russian Academy of Sciences, 142432 Chernogolovka, Russia.ORCID 0000-0002-8136-6906
Nadezhda V KovalevaInstitute of Physiologically Active Compounds Russian Academy of Sciences, 142432 Chernogolovka, Russia.ORCID 0000-0002-4990-5068
Elena V RudakovaInstitute of Physiologically Active Compounds Russian Academy of Sciences, 142432 Chernogolovka, Russia.ORCID 0000-0002-4600-7799
Natalia P BoltnevaInstitute of Physiologically Active Compounds Russian Academy of Sciences, 142432 Chernogolovka, Russia.ORCID 0000-0002-7171-8832
Sofya V LushchekinaInstitute of Physiologically Active Compounds Russian Academy of Sciences, 142432 Chernogolovka, Russia.ORCID 0000-0002-6922-020X
Irina I FaingoldInstitute of Problems of Chemical Physics of Russian Academy of Sciences, 142432 Chernogolovka, Russia.
Darya A PoletaevaInstitute of Problems of Chemical Physics of Russian Academy of Sciences, 142432 Chernogolovka, Russia.ORCID 0000-0002-4315-9180
Yuliya V SoldatovaInstitute of Problems of Chemical Physics of Russian Academy of Sciences, 142432 Chernogolovka, Russia.ORCID 0000-0002-6929-0638
Raisa A KotelnikovaInstitute of Problems of Chemical Physics of Russian Academy of Sciences, 142432 Chernogolovka, Russia.
Igor V SerkovInstitute of Physiologically Active Compounds Russian Academy of Sciences, 142432 Chernogolovka, Russia.
Anatoly K UstinovInstitute of Physiologically Active Compounds Russian Academy of Sciences, 142432 Chernogolovka, Russia.
Alexey N ProshinInstitute of Physiologically Active Compounds Russian Academy of Sciences, 142432 Chernogolovka, Russia.
Eugene V RadchenkoInstitute of Physiologically Active Compounds Russian Academy of Sciences, 142432 Chernogolovka, Russia.ORCID 0000-0002-2091-7022
Vladimir A PalyulinInstitute of Physiologically Active Compounds Russian Academy of Sciences, 142432 Chernogolovka, Russia.ORCID 0000-0001-8792-8386
Rudy J RichardsonDepartment of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-2028-5723
Funding
Alternatives Research and Development Foundation 015905IPAC RAS State Targets Project 0090-2019-0005Ministry of Science and Higher Education of the Russian Federation 075-15-2020-777Russian Foundation for Basic Research 20-03-00590_a
Abstract
New hybrids of 4-amino-2,3-polymethylenequinoline with different sizes of the aliphatic ring linked to butylated hydroxytoluene (BHT) by enaminoalkyl (
Indexed as
Alzheimer DiseaseAnimalsAntioxidantsButylated HydroxytolueneCholinesterase InhibitorsHumansMiceMolecular Docking SimulationPropidiumAntioxidantsButylated HydroxytolueneCholinesterase InhibitorsPropidium4-amino-2,3-polymethylenequinolinesacetylcholinesterase (AChE)ADMETAlzheimer’s disease (AD)antioxidantsbutylated hydroxytoluene (BHT)butyrylcholinesterase (BChE)neuroprotection
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.