Evidence map›Paper›PMID 33322727›Full record

ArticleCells2020

Preemptive Analgesic Effect of Intrathecal Applications of Neuroactive Steroids in a Rodent Model of Post-Surgical Pain: Evidence for the Role of T-Type Calcium Channels.

Quy L Tat, Srdjan M Joksimovic, Kathiresan Krishnan, Douglas F Covey, Slobodan M Todorovic, Vesna Jevtovic-Todorovic

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. New directions in neurosteroid therapeutics in neuropsychiatry.Neuroscience and biobehavioral reviews · 2025
    Review
  3. Molecular pharmacology · 2024
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Quy L TatDepartment of Anesthesiology, School of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA.
Srdjan M JoksimovicDepartment of Anesthesiology, School of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA.
Kathiresan KrishnanDepartment of Developmental Biology, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA.
Douglas F CoveyDepartment of Developmental Biology, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA.
Slobodan M TodorovicDepartment of Anesthesiology, School of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA.
Vesna Jevtovic-TodorovicDepartment of Anesthesiology, School of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA.
University of Colorado Anschutz Medical Campus · USUniversity of Colorado Denver · USWashington University in St. Louis · US

Funding

Novel neurosteroid anesthetics and developmental synaptogenesisR01HD097990 · NICHD · UNIVERSITY OF COLORADO DENVER · PI JEVTOVIC-TODOROVIC, VESNA · 2019 to 2023
$2.9M
Novel neurosteroid anesthetics and perioperative analgesiaR01GM123746 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI JEVTOVIC-TODOROVIC, VESNA · 2017 to 2025
$2.2M
NICHD NIH HHS R01 HD097990NIGMS NIH HHS R01 GM123746
6 · The paper itself

Abstract

Preemptive management of post-incisional pain remains challenging. Here, we examined the role of preemptive use of neuroactive steroids with activity on low-voltage activated T-type Ca

Indexed as

AnalgesicsAnimalsCalcium Channels, T-TypeDisease Models, AnimalFemaleHyperalgesiaInjections, SpinalMorphineNeurosteroidsPostoperative PainPregnanedionesRats, Sprague-DawleyalphaxaloneAnalgesicsCalcium Channels, T-TypeMorphineNeurosteroidsPregnanedionesadult female ratsGABAergicincision painmechanical hypersensitivitymorphinevoltage-gated calcium channels

Identifiers

PMID33322727
PMCPMC7763050
OpenAlexW3113104255

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.