Evidence map›Paper›PMID 33322704›Full record

ArticleJournal of clinical medicine2020

The Expression Patterns of

Martyna Bednarczyk, Edyta Fatyga, Sylwia Dzięgielewska-Gęsiak, Dariusz Waniczek, Beniamin Grabarek, Nikola Zmarzły, Grażyna Janikowska, Małgorzata Muc-Wierzgoń

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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  8. Frontiers in oncology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Martyna BednarczykDepartment of Internal Medicine, Medical University of Silesia in Katowice, 40-055 Katowice, Poland.
Edyta FatygaDepartment of Internal Medicine, Medical University of Silesia in Katowice, 40-055 Katowice, Poland.
Sylwia Dzięgielewska-GęsiakDepartment of Internal Medicine, Medical University of Silesia in Katowice, 40-055 Katowice, Poland.ORCID 0000-0003-1019-5959
Dariusz WaniczekDepartment of Propedeutics Surgery, Chair of General, Colorectal and Polytrauma Surgery, Medical University of Silesia in Katowice, SHS in Katowice, 40-055 Katowice, Poland.
Beniamin GrabarekDepartment of Histology, Cytophysiology and Embryology, Faculty of Medicine in Zabrze, University of Technology in Katowice, 40-055 Katowice, Poland.ORCID 0000-0003-1633-7145
Nikola ZmarzłyDepartment of Histology, Cytophysiology and Embryology, Faculty of Medicine in Zabrze, University of Technology in Katowice, 40-055 Katowice, Poland.ORCID 0000-0002-7833-6167
Grażyna JanikowskaDepartment of Analytical Chemistry, Medical University of Silesia in Katowice, 40-055 Katowice, Poland.
Małgorzata Muc-WierzgońDepartment of Internal Medicine, Medical University of Silesia in Katowice, 40-055 Katowice, Poland.ORCID 0000-0001-6562-7072
Medical University of Silesia · PLAkademia Śląska · PL

Funding

Supported by grants from Medical University of Silesia Agreement Grant number (no:KNW-1-072/K/9/K)
6 · The paper itself

Abstract

backgroundAutophagy plays a dual role of tumor suppression and tumor promotion in colorectal cancer. The study aimed to find those microRNAs (miRNAs) important in

methodsA total of 44 pairs of surgically removed tumors at clinical stages I‒IV and healthy samples (marginal tissues) from patients' guts were analyzed. Analysis of the obtained results was conducted using the PL-Grid Infrastructure and Statistica 12.0 program. The miRNAs and CpG islands were estimated using the microrna.org database and MethPrimer program.

resultsThe autophagy-related genes were shown to be able to be regulated by miRNAs (

conclusionsThe in silico analysis performed allowed us to determine the possible role of epigenetic mechanisms of regulation gene expression, which may be an interesting therapeutic target in the treatment of colorectal cancer.

Indexed as

autophagycolorectal cancerCpG islandsexpression genesmicroRNAs (miRNAs)

Identifiers

PMID33322704
PMCPMC7764710
OpenAlexW3112365599

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.