Evidence map›Paper›PMID 33322622›Full record

ReviewCancers2020

Cardiovascular Health during and after Cancer Therapy.

Kathryn J Ruddy, Shruti R Patel, Alexandra S Higgins, Saro H Armenian, Joerg Herrmann

Abstract readReview
In one paragraph

Review in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kathryn J RuddyDepartment of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Shruti R PatelDepartment of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Alexandra S HigginsDepartment of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Saro H ArmenianDepartment of Population Sciences, City of Hope, Duarte, CA 91010, USA.ORCID 0000-0003-2604-8603
Joerg HerrmannDepartment of Cardiovascular Disease, Mayo Clinic, Rochester, MN 55905, USA.

Funding

TrAstuzumab Cardiomyopathy Therapeutic Intervention with Carvedilol (TACTIC) TrialR01CA233610 · NCI · MAYO CLINIC ROCHESTER · PI HERRMANN, JOERG, RUDDY, KATHRYN JEAN · 2019 to 2024
$4.3M
Cardiovascular reserve capacity in survivors of hematopoietic cell transplantationR01HL150069 · NHLBI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI ARMENIAN, SARO · 2020 to 2024
$3.5M
Lymphoma & Leukemia Society Scholar AwardNCI NIH HHS R01CA 233610-2NCI NIH HHS R01 HL150069
6 · The paper itself

Abstract

Certain cancer treatments have been linked to specific cardiovascular toxicities, including (but not limited to) cardiomyopathy, atrial fibrillation, arterial hypertension, and myocarditis. Radiation, anthracyclines, human epidermal growth factor receptor 2 (Her2)-directed therapies, fluoropyrimidines, platinums, tyrosine kinase inhibitors and proteasome inhibitors, immune checkpoint inhibitors, and chimeric antigen-presenting (CAR)-T cell therapy can all cause cardiovascular side effects. Management of cardiovascular dysfunction that occurs during cancer therapy often requires temporary or permanent cessation of the risk-potentiating anti-neoplastic drug as well as optimization of medical management from a cardiovascular standpoint. Stem cell or bone marrow transplant recipients face unique cardiovascular challenges, as do patients at extremes of age.

Indexed as

anthracyclinecardio-oncologycongestive heart failuremyocarditis

Identifiers

PMID33322622
PMCPMC7763346

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.