Evidence map›Paper›PMID 33322618›Full record

ArticleCancers2020

Circulating Tumour DNA Sequencing Identifies a Genetic Resistance-Gap in Colorectal Cancers with Acquired Resistance to EGFR-Antibodies and Chemotherapy.

Franciele H Knebel, Louise J Barber, Alice Newey, Dimitrios Kleftogiannis, Andrew Woolston, Beatrice Griffiths, Kerry Fenwick, Fabiana Bettoni, Maurício Fernando Silva Almeida Ribeiro, Leonardo da Fonseca and 6 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Circulating Tumor DNA to Drive Treatment in Metastatic Colorectal Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Franciele H KnebelTranslational Oncogenomics Lab, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.
Louise J BarberTranslational Oncogenomics Lab, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.ORCID 0000-0001-9265-3516
Alice NeweyTranslational Oncogenomics Lab, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.
Dimitrios KleftogiannisCentre for Evolution and Cancer, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.ORCID 0000-0003-1086-821X
Andrew WoolstonTranslational Oncogenomics Lab, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.
Beatrice GriffithsTranslational Oncogenomics Lab, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.
Kerry FenwickTumour Profiling Unit, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.
Fabiana BettoniSociedade Beneficiente de Senhoras Hospital Sírio Libanês, SBSHSL, Rua Dona Adma Jafet 91, São Paulo 01308-050, SP, Brazil.ORCID 0000-0002-6611-7442
Maurício Fernando Silva Almeida RibeiroSociedade Beneficiente de Senhoras Hospital Sírio Libanês, SBSHSL, Rua Dona Adma Jafet 91, São Paulo 01308-050, SP, Brazil.
Leonardo da FonsecaSociedade Beneficiente de Senhoras Hospital Sírio Libanês, SBSHSL, Rua Dona Adma Jafet 91, São Paulo 01308-050, SP, Brazil.
Frederico CostaSociedade Beneficiente de Senhoras Hospital Sírio Libanês, SBSHSL, Rua Dona Adma Jafet 91, São Paulo 01308-050, SP, Brazil.
Fernanda Cunha CapareliSociedade Beneficiente de Senhoras Hospital Sírio Libanês, SBSHSL, Rua Dona Adma Jafet 91, São Paulo 01308-050, SP, Brazil.
Paulo M HoffInstituto D'Or de Pesquisa e Ensino, IDOR, Oncologia D'Or, Avenida República do Líbano 611, São Paulo 04.502-001, SP, Brazil.
Jorge SabbagaSociedade Beneficiente de Senhoras Hospital Sírio Libanês, SBSHSL, Rua Dona Adma Jafet 91, São Paulo 01308-050, SP, Brazil.
Anamaria A CamargoSociedade Beneficiente de Senhoras Hospital Sírio Libanês, SBSHSL, Rua Dona Adma Jafet 91, São Paulo 01308-050, SP, Brazil.ORCID 0000-0002-6076-9597
Marco GerlingerTranslational Oncogenomics Lab, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.ORCID 0000-0003-2719-299X
Associação de Assistência à Criança Deficiente · BRInstitute of Cancer Research · GBD’Or Institute for Research and Education · BRRoyal Marsden NHS Foundation Trust · GB

Funding

Cancer Research UK 18377
6 · The paper itself

Abstract

Epidermal growth factor receptor antibodies (EGFR-Abs) confer a survival benefit in patients with

Indexed as

acquired resistancecolorectal cancerctDNA-ddPCRctDNA-SequencingEGFR-antibodiesgenetic resistance-gap

Identifiers

PMID33322618
PMCPMC7764102
OpenAlexW3113105109

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.