Molecular Diversity via Tetrasubstituted Alkenes Containing a Barbiturate Motif: Synthesis and Biological Activity.

Ahmed Al-Sheikh, Masuma Begum, Bian Zhang, Richard A Lewis, Nicholas E E Allenby, Paul G Waddell, Bernard T Golding

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Electrosynthesis of 1,1-Bis(difluoromethyl)alkenes via Twofold C-H Difluoromethylation as Bioisosteres of Elusive 1,1-Enediols.Nature communications · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ahmed Al-SheikhFaculty of Pharmacy, University of Petra, P.O. Box 961343, Amman 11196, Jordan.ORCID 0000-0002-5310-7923

Masuma BegumBiBerChem Research Ltd., The Biosphere, Draymans Way, Newcastle Helix, Newcastle upon Tyne NE4 5BX, UK.

Bian ZhangBiBerChem Research Ltd., The Biosphere, Draymans Way, Newcastle Helix, Newcastle upon Tyne NE4 5BX, UK.

Richard A LewisDemuris Ltd., The Biosphere, Draymans Way, Newcastle Helix, Newcastle upon Tyne NE4 5BX, UK.

Nicholas E E AllenbyDemuris Ltd., The Biosphere, Draymans Way, Newcastle Helix, Newcastle upon Tyne NE4 5BX, UK.

Paul G WaddellChemical Crystallography Unit, School of Natural & Environmental Sciences, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.

Bernard T GoldingBiBerChem Research Ltd., The Biosphere, Draymans Way, Newcastle Helix, Newcastle upon Tyne NE4 5BX, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The synthesis of a molecularly diverse library of tetrasubstituted alkenes containing a barbiturate motif is described. Base-induced condensation of

Indexed as

Microbial Sensitivity TestsAlkenesAnti-Bacterial AgentsAntifungal AgentsBarbituratesBiological AssayCandida albicansEscherichia coliInhibitory Concentration 50Molecular ConformationPyransSchizosaccharomycesStaphylococcus aureusStructure-Activity RelationshipTrifluoroethanolAlkenesAnti-Bacterial AgentsAntifungal AgentsBarbituratesbarbituric acidPyransTrifluoroethanolantibacterialantifungalbarbiturate templatemolecular diversitytrifluoroethanol

Identifiers

PMID33322563

DOI10.3390/molecules25245868

PMCPMC7763037

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.