Evidence map›Paper›PMID 33322503›Full record

ArticleNanomaterials (Basel, Switzerland)2020

Biocompatible SWCNT Conductive Composites for Biomedical Applications.

Aleksandr Markov, Roger Wördenweber, Levan Ichkitidze, Alexander Gerasimenko, Ulyana Kurilova, Irina Suetina, Marina Mezentseva, Andreas Offenhäusser, Dmitry Telyshev

Abstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aleksandr MarkovInstitute for Bionic Technologies and Engineering, I. M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia.ORCID 0000-0002-3194-6064
Roger WördenweberInstitute of Biological Information Processing, Bioelectronics (IBI-3), Research Center Jülich, 52425 Jülich, Germany.
Levan IchkitidzeInstitute for Bionic Technologies and Engineering, I. M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
Alexander GerasimenkoInstitute for Bionic Technologies and Engineering, I. M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia.ORCID 0000-0001-6514-2411
Ulyana KurilovaInstitute of Biomedical Systems, National Research University of Electronic Technology, Zelenograd, 124498 Moscow, Russia.
Irina SuetinaIvanovsky Institute of Virology, N. F. Gamaleya National Center of Epidemiology and Microbiology, 123098 Moscow, Russia.
Marina MezentsevaIvanovsky Institute of Virology, N. F. Gamaleya National Center of Epidemiology and Microbiology, 123098 Moscow, Russia.
Andreas OffenhäusserInstitute of Biological Information Processing, Bioelectronics (IBI-3), Research Center Jülich, 52425 Jülich, Germany.ORCID 0000-0001-6143-2702
Dmitry TelyshevInstitute for Bionic Technologies and Engineering, I. M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia.ORCID 0000-0002-4221-9882

Funding

Russian academic excellence project "5-100" for Sechenov First Moscow State Medical University 5-100Russian Science Foundation 19-79-00333
6 · The paper itself

Abstract

The efficiency of devices for biomedical applications, including tissue engineering and neuronal stimulation, heavily depends on their biocompatibility and performance level. Therefore, it is important to find adequate materials that meet the necessary requirements such as (i) being intrinsically compatible with biological systems, (ii) providing a sufficient electronic conductivity that promotes efficient signal transduction, (iii) having "soft" mechanical properties comparable to biological structures, and (iv) being degradable in physiological solution. We have developed organic conducting biocompatible single-walled carbon nanotubes (SWCNT) composites based on bovine serum albumin, carboxymethylcellulose, and acrylic polymer and investigated their properties, which are relevant for biomedical applications. This includes ζ-potential measurements, conductivity analyses, and SEM micrographs, the latter providing a local analysis of SWCNT distribution in the base material. We observed the development of the electrical conductivity of the SWCNT composites exposed to 1 mM KCl electrolyte for 40 days, representing a high stability of the samples. The conductivity of samples reaches 1300 S/m for 0.45 wt.% nanotubes. Moreover, we demonstrated the biocompatibility of the composites via cultivating fibroblast cell culture. Finally, we showed that composite coating results in the longer lifespan of cells on the surface. Overall, the SWCNT-based conductive composites might be a promising material for extended biomedical applications.

Indexed as

biocompatibilitybovine serum albumincarboxymethylcelluloseconductive compositesfibroblasts

Identifiers

PMID33322503
PMCPMC7763503

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.