ArticleMaterials (Basel, Switzerland)2020
A New Generation of Electrospun Fibers Containing Bioactive Glass Particles for Wound Healing.
Article in Materials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Janus bilayer coating of functional quaternized chitosan and borate bioactive glass for antibacterial protection and osseointegration.Biomaterials advances · 2026Article
- Article
- Incorporation of Poly(propylene succinate-ACS applied bio materials · 2025Article
- Article
- Electrospun Nanomaterials Based on Cellulose and Its Derivatives for Cell Cultures: Recent Developments and Challenges.Polymers · 2023Review
- Modified Sol-Gel Synthesis of Mesoporous Borate Bioactive Glasses for Potential Use in Wound Healing.Bioengineering (Basel, Switzerland) · 2022Article
- Cell loaded hydrogel containing Ag-doped bioactive glass-ceramic nanoparticles as skin substitute: Antibacterial properties, immune response, and scarless cutaneous wound regeneration.Bioengineering & translational medicine · 2022Article
- Bioactive glass-based fibrous wound dressings.Burns & trauma · 2022Review
- Mesoporous Silica Nanoparticles and Mesoporous Bioactive Glasses for Wound Management: From Skin Regeneration to Cancer Therapy.Materials (Basel, Switzerland) · 2021Review
- Hemostatic and Tissue Regeneration Performance of Novel Electrospun Chitosan-Based Materials.Biomedicines · 2021Article
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Authors and funding
4 authors.
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Abstract
Chitosan fibers blended with polyethylene oxide (CHIT_PEO) and crosslinked with genipin were fabricated by electrospinning technique. Subsequently, CHIT_PEO bioactive glass composite electrospun mats were fabricated with the aim to achieve flexible structures with adequate mechanical properties and improved biological performance respect to CHIT_PEO fibers, for potential applications in wound healing. Three different compositions of bioactive glasses (BG) were selected and investigated: 45S5 BG, a Sr and Mg containing bioactive glass (BGMS10) and a Zn-containing bioactive glass (BGMS_2Zn). Particulate BGs (particles size < 20 μm) were separately added to the starting CHIT_PEO solution before electrospinning. The two recently developed bioactive glasses (BGMS10 and BGMS_2Zn) showed very promising biological properties in terms of bioactivity and cellular viability; thus, such compositions were added for the first time to CHIT_PEO solution to fabricate composite electrospun mats. The incorporation of bioactive glass particles and their distribution into CHIT_PEO fibers were assessed by SEM and FTIR analyses. Furthermore, CHIT_PEO composite electrospun mats showed improved mechanical properties in terms of Young's Modulus compared to neat CHIT_PEO fibers; on the contrary, the values of tensile strain at break (%) were comparable. Biological performance in terms of cellular viability was investigated by means of WST-8 assay and CHIT_PEO composite electrospun mats showed cytocompatibility and the desired cellular viability.
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