Evidence map›Paper›PMID 33322333›Full record

ArticleMicroorganisms2020

Effects of Different Drug Combinations in Immunodeficient Mice Infected with an Influenza A/H3N2 Virus.

Zeineb Mhamdi, Hugues Fausther-Bovendo, Olus Uyar, Julie Carbonneau, Marie-Christine Venable, Yacine Abed, Gary Kobinger, Guy Boivin, Mariana Baz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Zeineb MhamdiResearch Center in Infectious Diseases of the CHU of Québec, Laval University, Québec City, QC G1V 4G2, Canada.
Hugues Fausther-BovendoResearch Center in Infectious Diseases of the CHU of Québec, Laval University, Québec City, QC G1V 4G2, Canada.
Olus UyarResearch Center in Infectious Diseases of the CHU of Québec, Laval University, Québec City, QC G1V 4G2, Canada.ORCID 0000-0002-6399-5573
Julie CarbonneauResearch Center in Infectious Diseases of the CHU of Québec, Laval University, Québec City, QC G1V 4G2, Canada.
Marie-Christine VenableResearch Center in Infectious Diseases of the CHU of Québec, Laval University, Québec City, QC G1V 4G2, Canada.
Yacine AbedResearch Center in Infectious Diseases of the CHU of Québec, Laval University, Québec City, QC G1V 4G2, Canada.
Gary KobingerResearch Center in Infectious Diseases of the CHU of Québec, Laval University, Québec City, QC G1V 4G2, Canada.
Guy BoivinResearch Center in Infectious Diseases of the CHU of Québec, Laval University, Québec City, QC G1V 4G2, Canada.
Mariana BazResearch Center in Infectious Diseases of the CHU of Québec, Laval University, Québec City, QC G1V 4G2, Canada.
Université Laval · CA

Funding

Canadian Institute of Health Research 229733
6 · The paper itself

Abstract

The prolonged treatment of immunosuppressed (IS) individuals with anti-influenza monotherapies may lead to the emergence of drug-resistant variants. Herein, we evaluated oseltamivir and polymerase inhibitors combinations against influenza A/H3N2 infections in an IS mouse model. Mice were IS with cyclophosphamide and infected with 3 × 10

Indexed as

baloxavir marboxilcombination therapyfavipiravirH3N2immunosuppressioninfluenzamiceoseltamivirresistance

Identifiers

PMID33322333
PMCPMC7764069
OpenAlexW3111301186

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.