Evidence map›Paper›PMID 33322318›Full record

SynthesisNutrients2020

Efficacy of Spice Supplementation in Rheumatoid Arthritis: A Systematic Literature Review.

Jean-Guillaume Letarouilly, Pauline Sanchez, Yann Nguyen, Johanna Sigaux, Sébastien Czernichow, René-Marc Flipo, Jérémie Sellam, Claire Daïen

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Effect ofNutrients · 2021
    Pooled it
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Potential Benefits of Curcumin in Rheumatoid Arthritis.American journal of lifestyle medicine
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Jean-Guillaume LetarouillyDepartment of Rheumatology, CHU Lille, Université de Lille, F-59000 Lille, France.ORCID 0000-0003-2793-6303
Pauline SanchezDepartment of Rheumatology, CHU de Montpellier, Montpellier University, 34295 Montpellier, France.
Yann NguyenDepartment of Internal Medicine, Hôpital Beaujon, AP-HP Nord, Université de Paris, F-92100 Clichy, France.ORCID 0000-0002-0866-3824
Johanna SigauxDepartment of Rheumatology, Hôpital Avicenne, AP-HP, INSERM U1125, Université Paris 13, F-93017 Bobigny, France.
Sébastien CzernichowDepartment of Nutrition, Specialized Obesity Center, Hôpital Européen Georges Pompidou, Université de Paris, AP-HP, F-75015 Paris, France.
René-Marc FlipoDepartment of Rheumatology, CHU Lille, Université de Lille, F-59000 Lille, France.
Jérémie SellamDMU 3ID, Hôpital Saint Antoine, AP-HP, CRSA Inserm UMRS_938, Sorbonne Université, F-75012 Paris, France.
Claire DaïenDepartment of Rheumatology, CHU de Montpellier, Montpellier University, 34295 Montpellier, France.
Inserm · FRUniversité de Lille · FRUniversité de Montpellier · FRHôpital Beaujon · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSpices, i.e., curcumin, ginger, saffron, and cinnamon, have a thousand-year history of medicinal use in Asia. Modern medicine has begun to explore their therapeutic properties during the last few decades. We aimed to perform a systematic literature review (SLR) of randomized controlled trials (RCTs) assessing the effect of spice supplementation on symptoms and disease activity in patients with chronic inflammatory rheumatic diseases (rheumatoid arthritis (RA), spondylarthritis, or psoriatic arthritis).

methodsAn SLR of RCTs, reviews, and meta-analyses was performed, searching for articles in MEDLINE/PubMed. Abstracts from international rheumatology and nutrition congresses (2017-2020) were also scrutinized. The risk of bias of the selected studies was evaluated using the Cochrane Collaboration's tool and the Jadad scale.

resultsAltogether, six studies, assessing the use of spice supplementation only in RA patients, were included: one on garlic supplementation, two on curcumin, one on ginger, one on cinnamon, and one on saffron supplementation. Garlic, ginger, cinnamon, or saffron supplementation was associated with a decrease in RA clinical activity. However, several points limit the external validity of these studies. No conclusion on the impact of curcumin supplementation on RA activity could be drawn due to low-quality studies.

conclusionsGarlic, ginger, cinnamon, and saffron supplementation could have a beneficial effect on RA activity, but the risk of bias of these studies is difficult to assess and data are too limited to recommend them in daily practice.

Indexed as

Dietary SupplementsSpicesAdultAntirheumatic AgentsArthritis, RheumatoidCinnamomum zeylanicumCrocusFemaleGarlicHumansMaleMiddle AgedRandomized Controlled Trials as TopicTreatment OutcomeZingiber officinaleAntirheumatic Agentscinnamoncurcumadisease activitygarlicgingerrheumatoid arthritissaffronspice

Identifiers

PMID33322318
PMCPMC7764619
OpenAlexW3111431852

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.