Evidence map›Paper›PMID 33322198›Full record

ArticleMolecules (Basel, Switzerland)2020

Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features.

Sk Sarif Hassan, Shinjini Ghosh, Diksha Attrish, Pabitra Pal Choudhury, Alaa A A Aljabali, Bruce D Uhal, Kenneth Lundstrom, Nima Rezaei, Vladimir N Uversky, Murat Seyran and 14 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  10. Implications derived from S-protein variants of SARS-CoV-2 from six continents.International journal of biological macromolecules · 2021
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  13. GB-2 blocking the interaction between ACE2 and wild type and mutation of spike protein of SARS-CoV-2.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Sk Sarif HassanDepartment of Mathematics, Pingla Thana Mahavidyalaya, Maligram 721140, India.ORCID 0000-0003-4331-722X
Shinjini GhoshDepartment of Biophysics, Molecular Biology and Bioinformatics, University of Calcutta, Kolkata 700009, India.
Diksha AttrishDr. B. R. Ambedkar Centre for Biomedical Research (ACBR), University of Delhi (North Campus), Delhi 110007, India.
Pabitra Pal ChoudhuryApplied Statistics Unit, Indian Statistical Institute, Kolkata 700108, West Bengal, India.ORCID 0000-0002-1440-1679
Alaa A A AljabaliDepartment of Pharmaceutics and Pharmaceutical Technology, Yarmouk University-Faculty of Pharmacy, Irbid 566, Jordan.ORCID 0000-0002-9519-6338
Bruce D UhalDepartment of Physiology, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0002-5201-432X
Kenneth LundstromPanTherapeutics, Rte de Lavaux 49, CH1095 Lutry, Switzerland.
Nima RezaeiResearch Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran 1416753955, Iran.ORCID 0000-0002-3836-1827
Vladimir N UverskyDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.ORCID 0000-0002-4037-5857
Murat SeyranDoctoral studies in natural and technical sciences (SPL 44), University of Vienna, 1010 Wien, Austria.
Damiano PizzolItalian Agency for Development Cooperation-Khartoum, Sudan Street 33, Al Amarat, Khartoum 825109, Sudan.ORCID 0000-0003-4122-0774
Parise AdadiDepartment of Food Science, University of Otago, Dunedin 9054, New Zealand.ORCID 0000-0003-4724-9463
Antonio SoaresDepartment of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 77030, USA.
Tarek Mohamed Abd El-AzizDepartment of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 77030, USA.ORCID 0000-0002-3441-9673
Ramesh KandimallaApplied Biology, CSIR-Indian Institute of Chemical Technology Uppal Road, Tarnaka, Hyderabad 500007, India.ORCID 0000-0002-3313-4393
Murtaza M TambuwalaSchool of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine BT52 1SA, Northern Ireland, UK.ORCID 0000-0001-8499-9891
Gajendra Kumar AzadDepartment of Zoology, Patna University, Patna, Bihar 800005, India.ORCID 0000-0001-5478-526X
Samendra P SherchanDepartment of Environmental Health Sciences, Tulane University, New Orleans, LA 70112, USA.
Wagner Baetas-da-CruzTranslational Laboratory in Molecular Physiology, Centre for Experimental Surgery, College of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941901, Brazil.
Kazuo TakayamaCenter for iPS Cell Research and Application, Kyoto University, Kyoto 606-8501, Japan.ORCID 0000-0002-1132-2457
Ángel Serrano-ArocaBiomaterials and Bioengineering Lab, Translational Research Centre San Alberto Magno, Catholic University of Valencia San Vicente Mártir, c/Guillem de Castro 94, 46001 Valencia, Spain.ORCID 0000-0002-9953-3848
Gaurav ChauhanSchool of Engineering and Sciences, Tecnologico de Monterrey, Av. Eugenio Garza Sada 2501 Sur, Monterrey 64849, Nuevo León, Mexico.
Giorgio PaluDepartment of Molecular Medicine, University of Padova, Via Gabelli 63, 35121 Padova, Italy.
Adam M BrufskyDivision of Hematology/Oncology, Department of Medicine, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.ORCID 0000-0001-8080-7960

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22-42, aa 79-84, and aa 330-393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the findings propose a possible SARS-CoV-2 transmission flow across these nineteen species.

Indexed as

Angiotensin-Converting Enzyme 2COVID-19SARS-CoV-2Spike Glycoprotein, CoronavirusAnimalsCatsCattleDogsHumansPan troglodytesProtein DomainsSpecies SpecificityACE2 protein, humanAngiotensin-Converting Enzyme 2Spike Glycoprotein, Coronavirusspike protein, SARS-CoV-2ACE2bioinformaticsSARS-CoV-2transmissionviral spike receptor-binding domain

Identifiers

PMID33322198
PMCPMC7763092

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.