Evidence map›Paper›PMID 33322195›Full record

ArticleInternational journal of molecular sciences2020

Recombination and Pol ζ Rescue Defective DNA Replication upon Impaired CMG Helicase-Pol ε Interaction.

Milena Denkiewicz-Kruk, Malgorzata Jedrychowska, Shizuko Endo, Hiroyuki Araki, Piotr Jonczyk, Michal Dmowski, Iwona J Fijalkowska

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Milena Denkiewicz-KrukInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5a, 02-106 Warsaw, Poland.
Malgorzata JedrychowskaInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5a, 02-106 Warsaw, Poland.
Shizuko EndoNational Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411-8540, Japan.
Hiroyuki ArakiNational Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411-8540, Japan.
Piotr JonczykInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5a, 02-106 Warsaw, Poland.
Michal DmowskiInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5a, 02-106 Warsaw, Poland.ORCID 0000-0002-6571-6259
Iwona J FijalkowskaInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5a, 02-106 Warsaw, Poland.
Institute of Biochemistry and Biophysics, Polish Academy of Sciences · PLNational Institute of Genetics · JP

Funding

Fundacja na rzecz Nauki Polskiej TEAM/2011-8/1Narodowym Centrum Nauki 2017/26/M/NZ3/01044
6 · The paper itself

Abstract

The CMG complex (Cdc45, Mcm2-7, GINS (Psf1, 2, 3, and Sld5)) is crucial for both DNA replication initiation and fork progression. The CMG helicase interaction with the leading strand DNA polymerase epsilon (Pol ε) is essential for the preferential loading of Pol ε onto the leading strand, the stimulation of the polymerase, and the modulation of helicase activity. Here, we analyze the consequences of impaired interaction between Pol ε and GINS in

Indexed as

Cell SurvivalDNA-Binding ProteinsDNA-Directed DNA PolymeraseDNA HelicasesDNA Polymerase IIDNA ReplicationFrameshifting, RibosomalG2 Phase Cell Cycle CheckpointsMinichromosome Maintenance ProteinsMutagenesisMutationMutation RateNuclear ProteinsProtein BindingRad52 DNA Repair and Recombination ProteinRecombination, GeneticCDC45 protein, S cerevisiaeDNA-Binding ProteinsDNA-Directed DNA PolymeraseDNA HelicasesDNA Polymerase IIDNA polymerase zetaMinichromosome Maintenance ProteinsNuclear ProteinsPFS1 protein, S cerevisiaeRad52 DNA Repair and Recombination ProteinRAD52 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsCMGE helicase-polymerase complexDNA polymerase epsilonDNA replication fidelityDRIMgenetic instabilityGINS complexpolymerase zetaPol εPol ζPSF1/GINS1recombinationrepeat tracts instability

Identifiers

PMID33322195
PMCPMC7762974
OpenAlexW3113081857

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.