Evidence map›Paper›PMID 33322107›Full record

ArticleBioengineering (Basel, Switzerland)2020

Depletion of Boric Acid and Cobalt from Cultivation Media: Impact on Recombinant Protein Production with

Alexander Pekarsky, Sophia Mihalyi, Maximilian Weiss, Andreas Limbeck, Oliver Spadiut

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Adapting Komagataella phaffii Cultivation Media to REACH Regulations.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  2. Engineering Biology of Yeast for Advanced Biomanufacturing.Bioengineering (Basel, Switzerland) · 2022
    Article
  3. From Yeast to Biotechnology.Bioengineering (Basel, Switzerland) · 2022
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Alexander PekarskyInstitute of Chemical, Environmental and Bioscience Engineering, TU Wien, Gumpendorferstrasse 1a, 1060 Vienna, Austria.ORCID 0000-0002-7330-9661
Sophia MihalyiInstitute of Chemical, Environmental and Bioscience Engineering, TU Wien, Gumpendorferstrasse 1a, 1060 Vienna, Austria.
Maximilian WeissInstitute of Chemical Technologies and Analytics, TU Wien, Getreidemarkt 9/164-I2AC, 1060 Vienna, Austria.ORCID 0000-0002-4312-9256
Andreas LimbeckInstitute of Chemical Technologies and Analytics, TU Wien, Getreidemarkt 9/164-I2AC, 1060 Vienna, Austria.ORCID 0000-0001-5042-2445
Oliver SpadiutInstitute of Chemical, Environmental and Bioscience Engineering, TU Wien, Gumpendorferstrasse 1a, 1060 Vienna, Austria.ORCID 0000-0003-0916-0644
TU Wien · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The REACH regulation stands for "Registration, Evaluation, Authorization and Restriction of Chemicals" and defines certain substances as harmful to human health and the environment. This urges manufacturers to adapt production processes. Boric acid and cobalt dichloride represent such harmful ingredients, but are commonly used in yeast cultivation media. The yeast

Indexed as

boric acidboroncobaltKomagataella phaffiiPichia pastorisprotein qualityREACH-regulationyeast

Identifiers

PMID33322107
PMCPMC7763993
OpenAlexW3113216324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.