Evidence map›Paper›PMID 33322039›Full record

ArticleGenes2020

Compensatory Response of the Somatotropic Axis from IGFBP-2b Gene Editing in Rainbow Trout (

Beth M Cleveland, Shiori Habara, Jin Oikawa, Lisa M Radler, Munetaka Shimizu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Beth M ClevelandNational Center for Cool and Cold Water Aquaculture, United States Department of Agriculture/Agricultural Research Service, Leetown, WV 25430, USA.
Shiori HabaraGraduate School of Environmental Science, Hokkaido University, Sapporo 060-0808, Japan.
Jin OikawaGraduate School of Environmental Science, Hokkaido University, Sapporo 060-0808, Japan.
Lisa M RadlerNational Center for Cool and Cold Water Aquaculture, United States Department of Agriculture/Agricultural Research Service, Leetown, WV 25430, USA.
Munetaka ShimizuFaculty of Fisheries Sciences, Hokkaido University, Hakodate 041-8611, Japan.
Hokkaido University · JPUnited States Department of Agriculture · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rainbow trout with gene editing-induced reductions in serum insulin-like growth factor binding protein (IGFBP)-2b exhibit similar growth performance compared to fish without IGFBP-2b gene disruption. The objective of this study is to determine how the components of the insulin-like growth factor (IGF)/IGFBP system respond to a reduction in serum IGFBP-2b abundance. Editing the IGFBP-2b genes in rainbow trout resulted in an 83% decrease in serum IGFBP-2b in mutants. This resulted in a 35% reduction in serum IGF-I, which was offset by reduced expression of hepatic

Indexed as

Fish ProteinsGene EditingGene Expression RegulationInsulin-Like Growth Factor Binding Protein 2MutationOncorhynchus mykissAnimalsInsulin-Like Growth Factor IMuscle, SkeletalSignal TransductionFish ProteinsInsulin-Like Growth Factor Binding Protein 2Insulin-Like Growth Factor ICRISPR/Cas9feed deprivationgene editingIGFIGFBPinsulin-like growth factorrainbow trout

Identifiers

PMID33322039
PMCPMC7763687
OpenAlexW3112851445

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.