Evidence map›Paper›PMID 33321960›Full record

ArticleMarine drugs2020

Antimicrobial Peptide Arenicin-1 Derivative Ar-1-(C/A) as Complement System Modulator.

Ilia A Krenev, Ekaterina S Umnyakova, Igor E Eliseev, Yaroslav A Dubrovskii, Nikolay P Gorbunov, Vladislav A Pozolotin, Alexei S Komlev, Pavel V Panteleev, Sergey V Balandin, Tatiana V Ovchinnikova and 2 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Immunomodulatory and Allergenic Properties of Antimicrobial Peptides.International journal of molecular sciences · 2022
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Ilia A KrenevDepartment of General Pathology and Pathological Physiology, Institute of Experimental Medicine, Acad. Pavlov Str. 12, 197376 Saint Petersburg, Russia.
Ekaterina S UmnyakovaDepartment of General Pathology and Pathological Physiology, Institute of Experimental Medicine, Acad. Pavlov Str. 12, 197376 Saint Petersburg, Russia.
Igor E EliseevNanobiotechnology Laboratory, Alferov University, Khlopin Str. 8/3, 194021 Saint Petersburg, Russia.ORCID 0000-0002-3344-2513
Yaroslav A DubrovskiiFaculty of Chemistry, Saint Petersburg State University, Universitetskaya Emb, 7/9, 199034 Saint Petersburg, Russia.
Nikolay P GorbunovDepartment of General Pathology and Pathological Physiology, Institute of Experimental Medicine, Acad. Pavlov Str. 12, 197376 Saint Petersburg, Russia.ORCID 0000-0003-4636-0565
Vladislav A PozolotinDepartment of General Pathology and Pathological Physiology, Institute of Experimental Medicine, Acad. Pavlov Str. 12, 197376 Saint Petersburg, Russia.
Alexei S KomlevDepartment of General Pathology and Pathological Physiology, Institute of Experimental Medicine, Acad. Pavlov Str. 12, 197376 Saint Petersburg, Russia.
Pavel V PanteleevM.M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Str., 16/10, 117997 Moscow, Russia.ORCID 0000-0001-8448-031X
Sergey V BalandinM.M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Str., 16/10, 117997 Moscow, Russia.ORCID 0000-0003-2651-3739
Tatiana V OvchinnikovaM.M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Str., 16/10, 117997 Moscow, Russia.ORCID 0000-0002-5950-249X
Olga V ShamovaDepartment of General Pathology and Pathological Physiology, Institute of Experimental Medicine, Acad. Pavlov Str. 12, 197376 Saint Petersburg, Russia.
Mikhail N BerlovDepartment of General Pathology and Pathological Physiology, Institute of Experimental Medicine, Acad. Pavlov Str. 12, 197376 Saint Petersburg, Russia.ORCID 0000-0001-5191-0467
Institute of Experimental Medicine · RUInstitute of Bioorganic Chemistry · RUSt Petersburg University · RUSechenov University · RU

Funding

Ministry of Science and Higher Education of the Russian Federation 0791-2020-0006Russian Foundation for Basic Research 18-54-80026
6 · The paper itself

Abstract

Antimicrobial peptides (AMPs) are not only cytotoxic towards host pathogens or cancer cells but also are able to act as immunomodulators. It was shown that some human and non-human AMPs can interact with complement proteins and thereby modulate complement activity. Thus, AMPs could be considered as the base for complement-targeted therapeutics development. Arenicins from the sea polychaete

Indexed as

AnimalsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesComplement ActivationComplement Inactivating AgentsErythrocytesEscherichia coliHelminth ProteinsHemolysisHumansListeria monocytogenesProtein ConformationRabbitsSheep, DomesticStructure-Activity RelationshipAnti-Bacterial AgentsAntimicrobial Cationic Peptidesarenicin-1, Arenicola marinaComplement Inactivating AgentsHelminth Proteinsantimicrobial peptidearenicincomplement regulationcomplement system

Identifiers

PMID33321960
PMCPMC7764584
OpenAlexW3112460027

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.