Evidence map›Paper›PMID 33321947›Full record

ReviewInternational journal of molecular sciences2020

Congestive Hepatopathy.

José Ignacio Fortea, Ángela Puente, Antonio Cuadrado, Patricia Huelin, Raúl Pellón, Francisco José González Sánchez, Marta Mayorga, María Luisa Cagigal, Inés García Carrera, Marina Cobreros and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 87 citations in OpenAlex.

  1. Cardio-hepatic injury phenotypes and short-term outcomes in acute decompensated heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
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  13. FIB-4 index predicts short-term mortality in Vietnamese acute heart failure patients.American heart journal plus : cardiology research and practice · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

José Ignacio ForteaGastroenterology and Hepatology Department, University Hospital Marqués de Valdecilla, 39008 Santander, Spain.ORCID 0000-0001-5255-9445
Ángela PuenteGastroenterology and Hepatology Department, University Hospital Marqués de Valdecilla, 39008 Santander, Spain.
Antonio CuadradoGastroenterology and Hepatology Department, University Hospital Marqués de Valdecilla, 39008 Santander, Spain.ORCID 0000-0002-1363-864X
Patricia HuelinGastroenterology and Hepatology Department, University Hospital Marqués de Valdecilla, 39008 Santander, Spain.
Raúl PellónRadiology Department, University Hospital Marqués de Valdecilla, 39008 Santander, Spain.
Francisco José González SánchezRadiology Department, University Hospital Marqués de Valdecilla, 39008 Santander, Spain.ORCID 0000-0003-4747-6930
Marta MayorgaPathological Anatomy Service, University Hospital Marqués de Valdecilla, 39008 Santander, Spain.
María Luisa CagigalPathological Anatomy Service, University Hospital Marqués de Valdecilla, 39008 Santander, Spain.ORCID 0000-0001-7564-0334
Inés García CarreraGastroenterology and Hepatology Department, University Hospital Marqués de Valdecilla, 39008 Santander, Spain.
Marina CobrerosGastroenterology and Hepatology Department, University Hospital Marqués de Valdecilla, 39008 Santander, Spain.ORCID 0000-0003-0640-6688
Javier CrespoGastroenterology and Hepatology Department, University Hospital Marqués de Valdecilla, 39008 Santander, Spain.ORCID 0000-0001-8248-0172
Emilio FábregaGastroenterology and Hepatology Department, University Hospital Marqués de Valdecilla, 39008 Santander, Spain.ORCID 0000-0003-1876-3973
Marqués de Valdecilla University Hospital · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver disease resulting from heart failure (HF) has generally been referred as "cardiac hepatopathy". One of its main forms is congestive hepatopathy (CH), which results from passive venous congestion in the setting of chronic right-sided HF. The current spectrum of CH differs from earlier reports with HF, due to ischemic cardiomyopathy and congenital heart disease having surpassed rheumatic valvular disease. The chronic passive congestion leads to sinusoidal hypertension, centrilobular fibrosis, and ultimately, cirrhosis ("cardiac cirrhosis") and hepatocellular carcinoma after several decades of ongoing injury. Contrary to primary liver diseases, in CH, inflammation seems to play no role in the progression of liver fibrosis, bridging fibrosis occurs between central veins to produce a "reversed lobulation" pattern and the performance of non-invasive diagnostic tests of liver fibrosis is poor. Although the clinical picture and prognosis is usually dominated by the underlying heart condition, the improved long-term survival of cardiac patients due to advances in medical and surgical treatments are responsible for the increased number of liver complications in this setting. Eventually, liver disease could become as clinically relevant as cardiac disease and further complicate its management.

Indexed as

Heart FailureHumansLiverLiver CirculationLiver Diseasescirrhosisheart failureheart transplantationportal hypertension

Identifiers

PMID33321947
PMCPMC7764741
OpenAlexW4239761414

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.