Evidence map›Paper›PMID 33321829›Full record

ArticleInternational journal of molecular sciences2020

Differential Contribution of N- and C-Terminal Regions of HIF1α and HIF2α to Their Target Gene Selectivity.

Antonio Bouthelier, Florinda Meléndez-Rodríguez, Andrés A Urrutia, Julián Aragonés

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Antonio BouthelierResearch Unit, Hospital Santa Cristina, Research Institute Princesa (IP), Autonomous University of Madrid, 28009 Madrid, Spain.
Florinda Meléndez-RodríguezResearch Unit, Hospital Santa Cristina, Research Institute Princesa (IP), Autonomous University of Madrid, 28009 Madrid, Spain.ORCID 0000-0002-1990-569X
Andrés A UrrutiaResearch Unit, Hospital Santa Cristina, Research Institute Princesa (IP), Autonomous University of Madrid, 28009 Madrid, Spain.ORCID 0000-0001-7945-5515
Julián AragonésResearch Unit, Hospital Santa Cristina, Research Institute Princesa (IP), Autonomous University of Madrid, 28009 Madrid, Spain.
Hospital Universitario Santa Cristina · ESInstituto de Salud Carlos III · ES

Funding

Fundació la Marató de TV3 534/C/2016Ministerio de Ciencia, Innovación y Universidades PID2019-106371RB-I00Ministerio de Economía y Competitividad SAF2016-76815
6 · The paper itself

Abstract

Cellular response to hypoxia is controlled by the hypoxia-inducible transcription factors HIF1α and HIF2α. Some genes are preferentially induced by HIF1α or HIF2α, as has been explored in some cell models and for particular sets of genes. Here we have extended this analysis to other HIF-dependent genes using in vitro WT8 renal carcinoma cells and in vivo conditional

Indexed as

AnimalsBasic Helix-Loop-Helix ProteinsBinding SitesCarbonic Anhydrase IXEndothelial PAS Domain-Containing Protein 1HEK293 CellsHumansHypoxia-Inducible Factor 1, alpha SubunitLarge Neutral Amino Acid-Transporter 1LiverLungMembrane ProteinsMiceMice, Inbred C57BLMitochondrial ProteinsProtein BindingBasic Helix-Loop-Helix ProteinsBNip3 protein, mouseCar9 protein, mouseCarbonic Anhydrase IXEndothelial PAS Domain-Containing Protein 1Hif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitLarge Neutral Amino Acid-Transporter 1Membrane ProteinsMitochondrial ProteinsSlc7a5 protein, mouseHIF1HIF2hypoxia-inducible factorsoxygentranscription

Identifiers

PMID33321829
PMCPMC7764359
OpenAlexW3112375742

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.