SynthesisMedicina (Kaunas, Lithuania)2020
Relationship between Night Shifts and Risk of Breast Cancer among Nurses: A Systematic Review.
Synthesis in Medicina (Kaunas, Lithuania), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Return to work for health professionals with breast cancer as health recipients: A systematized review.Work (Reading, Mass.) · 2026Pooled it
- Night shift work and breast cancer risk in healthcare workers: a systematic review and meta-analysis.Occupational medicine (Oxford, England) · 2025Pooled it
- Prognostic factors affecting return to work in cancer patients: a systematic review.Occupational and environmental medicine · 2025Pooled it
- Work as a social risk factor in pregnancy: A systematic review of screening practices related to working conditions and family leave among pregnant adults.Birth (Berkeley, Calif.) · 2023Pooled it
- Trial
- Observational
- Association Between Occupation and Cancer Risk: A Large-scale Case-control Study in Japan.Journal of occupational and environmental medicine · 2026Article
- Rethinking shifts: shift length, diurnal variability, and long-term health risks for emergency medicine physicians.Internal and emergency medicine · 2026Review
- Article
- Navigating emotional and professional challenges: Israeli nurses' experiences in breast cancer surgery preparation.BMC nursing · 2026Article
- Chrono-Pharmacology for Cancer: Harnessing Circadian Regulations of the Cell Cycle and Immune Response Dynamics for Precision Therapy.ACS pharmacology & translational science · 2025Review
- The multifaceted impact of circadian disruption on cancer risk: a systematic review of insights and economic implications.Journal of the National Cancer Center · 2025Review
- Emergency Department Patient Satisfaction Scores Are Lower for Patients Who Arrive During the Night Shift.The western journal of emergency medicine · 2024Article
- Significance of Melatonin in the Regulation of Circadian Rhythms and Disease Management.Molecular neurobiology · 2024Review
- Circadian rhythm disruption and endocrine-related tumors.World journal of clinical oncology · 2024Review
- Exploring drivers of women's well-being in hospitals: mapping the landscape.BMC women's health · 2024Article
- The effects of psychological flexibility and night shifts on mental health and well-being in nurses.PloS one · 2024Article
- Article
- Review
- Role of Melatonin in Cancer: Effect on Clock Genes.International journal of molecular sciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
objectivesThe incidence of breast cancer worldwide has increased in recent decades, accounting for 1 in 3 neoplasms in women. Besides, nurses are mainly represented by the female collective, most of them, undertaking working conditions with intensive rotative and night shifts due to the 24-h pace of work of this profession. The objective of this study was to assess the possible relationship between shift work, especially night-time work, and the development of breast cancer among nurses. MATERIALS AND
methodsA systematic review of the literature was carried out through the consultation of the following databases: Cochrane Plus Library, PubMed, CINAHL (Cumulative Index to Nursing and Allied Health Literature), Web of Science, ScienceDirect, Scopus, and Dialnet. Records were selected between 2010 and 2020, in Spanish and English, which covered the association between breast cancer diagnosed among nursing professionals and rotating night shifts.
resultsA total of 12 studies were identified after critical reading. Most of the studies found an association between breast cancer and consecutive rotating night shifts prolonged over time. Among the associated factors, the alteration of the circadian rhythm influenced the expression of peripheral clock genes, which was the same as reproductive hormones. The risk of breast cancer in nurses increased during early adulthood and after 5 or more years with 6 or more consecutive nights.
conclusionsThe different studies of this review show significant associations between breast cancer and prolonged rotating night shifts. Similarly, there is a relationship between the alterations in certain circadian rhythm markers (such as melatonin), epigenetic markers (such as telomeres), and breast cancer that would require more studies in order to corroborate these findings.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.