Evidence map›Paper›PMID 33321550›Full record

ArticleESC heart failure2021

Heart failure is independently associated with white matter lesions: insights from the population-based LIFE-Adult Study.

Tina Stegmann, Mai L Chu, Veronica A Witte, Arno Villringer, Deniz Kumral, Steffi G Riedel-Heller, Susanne Roehr, Andreas Hagendorff, Ulrich Laufs, Markus Loeffler and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Tina StegmannClinic and Policlinic for Cardiology, University Hospital Leipzig, Leipzig, Germany.
Mai L ChuUniversity of Leipzig, Institute for Medical Informatics, Statistics and Epidemiology (IMISE), Leipzig, Germany.
Veronica A WitteDepartment of Neurology, Max Planck Institute for Human Cognitive and Brain Science, Leipzig, Germany.
Arno VillringerDepartment of Neurology, Max Planck Institute for Human Cognitive and Brain Science, Leipzig, Germany.
Deniz KumralDepartment of Neurology, Max Planck Institute for Human Cognitive and Brain Science, Leipzig, Germany.
Steffi G Riedel-HellerPublic Health Research Unit and Department of Social Medicine, University of Leipzig, Leipzig, Germany.
Susanne RoehrPublic Health Research Unit and Department of Social Medicine, University of Leipzig, Leipzig, Germany.
Andreas HagendorffClinic and Policlinic for Cardiology, University Hospital Leipzig, Leipzig, Germany.
Ulrich LaufsClinic and Policlinic for Cardiology, University Hospital Leipzig, Leipzig, Germany.
Markus LoefflerUniversity of Leipzig, Institute for Medical Informatics, Statistics and Epidemiology (IMISE), Leipzig, Germany.
Rolf WachterClinic and Policlinic for Cardiology, University Hospital Leipzig, Leipzig, Germany.
Samira ZeynalovaClinic and Policlinic for Cardiology, University Hospital Leipzig, Leipzig, Germany.
Leipzig University · DEMax Planck Institute for Human Cognitive and Brain Sciences · DEUniversity Hospital Leipzig · DELeipzig University of Applied Sciences · DEUniversitätsmedizin Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsWhite matter lesions (WML) are common structural alterations in the white matter of the brain and their prevalence increases with age. They are associated with cerebral ischaemia and cognitive dysfunction. Patients with heart failure (HF) are at risk for cognitive decline. We hypothesized that the presence and duration of HF are associated with WML. METHODS AND

resultsThe LIFE-Adult Study is a population-based study of 10 000 residents of Leipzig, Germany. WML were quantitated in 2490 participants who additionally underwent cerebral MRI using the Fazekas score. Mean age was 64 years, and 46% were female; 2156 (86.6%) subjects had Fazekas score of 0-1, and 334 (13.4%) had Fazekas score of 2-3. Thirty participants had a medical history of HF, 1019 had hypertension, and 51 had a history of stroke. Median left ventricular ejection fraction of the participants with HF was 57% (interquartile ranges 54-62). Age, troponin T, NT-proBNP, body mass index, history of acute myocardial infarction, stroke, HF, and diabetes were positively associated with WML in univariate analysis. On multivariate analysis, age, hypertension, stroke, and HF were independently associated with WML. The odd's ratio for the association of WML (Fazekas 2-3) with HF was 2.8 (95% CI 1.2-6.5; P = 0.019). WML increased with longer duration of HF (P = 0.036 for trend).

conclusionsIn addition to age, hypertension, and stroke, the prevalence and duration of HF are independently associated with WML. This observation sets the stage to investigate the prognostic value of WML in HF and the impact of HF therapies on WML.

Indexed as

Heart FailureWhite MatterAdultFemaleGermanyHumansMiddle AgedStroke VolumeVentricular Function, LeftCognitive impairmentHeart failureMagnetic resonance imagingPopulation-based studyWhite matter lesions

Identifiers

PMID33321550
PMCPMC7835595
OpenAlexW3111758536

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.