Evidence map›Paper›PMID 33321420›Full record

ArticleBioorganic & medicinal chemistry2021

Chemo-enzymatic synthesis of adenine substituted nicotinic acid adenine dinucleotide phosphate (NAADP) analogs.

Peiling Su, James D Bretz, Gihan S Gunaratne, Jonathan S Marchant, Timothy F Walseth, James T Slama

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. NAADP-Evoked CaHandbook of experimental pharmacology · 2023
    Article
  4. NAADP: From Discovery to Mechanism.Frontiers in immunology · 2021
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Peiling SuDepartment of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, 3000 Arlington Avenue, Toledo, OH 43614, United States.
James D BretzDepartment of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, 3000 Arlington Avenue, Toledo, OH 43614, United States.
Gihan S GunaratneDepartment of Pharmacology, University of Minnesota Medical School, 312 Church St., Minneapolis, MN 55455-0217, United States; Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226-0509, United States.
Jonathan S MarchantDepartment of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226-0509, United States.
Timothy F WalsethDepartment of Pharmacology, University of Minnesota Medical School, 312 Church St., Minneapolis, MN 55455-0217, United States. Electronic address: walse001@umn.edu.
James T SlamaDepartment of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, 3000 Arlington Avenue, Toledo, OH 43614, United States. Electronic address: james.slama@utoledo.edu.
University of Toledo · USMedical College of Wisconsin · USUniversity of Minnesota · US

Funding

Functional architecture of IP3-evoked local Ca2+ signalsR01GM088790 · NIGMS · UNIVERSITY OF MINNESOTA · PI MARCHANT, JONATHAN S, SLAMA, JAMES T · 2009 to 2025
$4.7M
Identification of the Elusive NAADP ReceptorR15GM131329 · NIGMS · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI SLAMA, JAMES T · 2018 to 2018
$462k
NIGMS NIH HHS R01 GM088790NIGMS NIH HHS R15 GM131329
6 · The paper itself

Abstract

Nicotinamide adenine dinucleotide phosphate (NADP) is an indispensable metabolic co-substrate and nicotinic acid adenine dinucleotide phosphate (NAADP) is an important Ca

Indexed as

AdenineAnimalsCalciumDose-Response Relationship, DrugHumansMolecular StructureNADPPhosphotransferases (Alcohol Group Acceptor)Sea UrchinsStructure-Activity RelationshipAdenineCalciumNAADPNAD kinaseNADPPhosphotransferases (Alcohol Group Acceptor)

Identifiers

PMID33321420
PMCPMC7869823
OpenAlexW3108819414

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.