Observational studyNutrition (Burbank, Los Angeles County, Calif.)2021
An exploratory study of selenium status in healthy individuals and in patients with COVID-19 in a south Indian population: The case for adequate selenium status.
Observational study in Nutrition (Burbank, Los Angeles County, Calif.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 3 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Selenium serum levels in patients with SARS-CoV-2 infection: a systematic review and meta-analysis.Journal of nutritional science · 2023Pooled it
- COVID-19 and Selenium Deficiency: a Systematic Review.Biological trace element research · 2022Pooled it
- Circulating trace elements status in COVID-19 disease: A meta-analysis.Frontiers in nutrition · 2022Pooled it
- Relation of Serum Copper Status to Survival in COVID-19.Nutrients · 2021Trial
- Assessment of micronutrient levels in patients with post COVID musculoskeletal manifestations - A cross-sectional observational study.Journal of family medicine and primary care · 2025Article
- Low urinary selenium concentration is associated with nonthyroidal illness syndrome in hospitalized patients with COVID-19.Archives of endocrinology and metabolism · 2025Article
- Oral Selenium as an Adjunct in the Treatment of Acute Lower Respiratory Tract Infections in Children.Indian pediatrics · 2025Article
- Zinc and selenium status in coronavirus disease 2019.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023Review
- Targeted Application of Functional Foods as Immune Fitness Boosters in the Defense against Viral Infection.Nutrients · 2023Review
- Could Selenium Supplementation Prevent COVID-19? A Comprehensive Review of Available Studies.Molecules (Basel, Switzerland) · 2023Review
- Observational
- Potential of Nano-Antioxidants and Nanomedicine for Recovery from Neurological Disorders Linked to Long COVID Syndrome.Antioxidants (Basel, Switzerland) · 2023Review
- Biogenic Selenium Nanoparticles in Biomedical Sciences: Properties, Current Trends, Novel Opportunities and Emerging Challenges in Theranostic Nanomedicine.Nanomaterials (Basel, Switzerland) · 2023Review
- Relationship between selenium status, selenoproteins and COVID-19 and other inflammatory diseases: A critical review.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2023Review
- Association of trace element status in COVID-19 patients with disease severity.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2022Article
- Antioxidant Effects of Dietary Supplements on Adult COVID-19 Patients: Why Do We Not Also Use Them in Children?Antioxidants (Basel, Switzerland) · 2022Review
- The Prevalence of Dietary Supplement Use for the Purpose of COVID-19 Prevention in Japan.Nutrients · 2022Article
- Nutraceuticals and Dietary Supplements for Older Adults with Long COVID-19.Clinics in geriatric medicine · 2022Review
- Evaluation of Serum Trace Element Levels and Biochemical Parameters of COVID-19 Patients According to Disease Severity.Biological trace element research · 2022Article
- The Perception of Minerals and Their Prevalence in Fortified Foods and Supplements in Japan.Nutrients · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has affected millions of individuals, causing major health and economic disruptions worldwide. The pandemic is still raging, with a second and third wave in a few countries, while new infections steadily rise in India. Nutrition and immune status are two critical aspects of fighting the virus successfully. Recently, selenium status was reported to positively correlate with the survival of patients with COVID-19 compared with non-survivors. We analyzed the blood serum levels in 30 apparently healthy individuals and in 30 patients with confirmed COVID-19 infection in the southern part of India. The patients showed significantly lower selenium levels of 69.2 ± 8.7 ng/mL than controls 79.1 ± 10.9 ng/mL. The difference was statistically significant (P = 0.0003). Interestingly, the control group showed a borderline level of selenium, suggesting that the level of this micronutrient is not optimum in the population studied. The results of this exploratory study pave the way for further research in a larger population and suggest that selenium supplementation may be helpful in reducing the effects of the virus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.