ArticleCirculation. Genomic and precision medicine2020
Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus.
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Article in Circulation. Genomic and precision medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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7citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 21% of its field
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Exploring associations between estrogen and gene candidates identified by coronary artery disease genome-wide association studies.Frontiers in cardiovascular medicine · 2025Pooled it
- Clinical use of polygenic scores in type 2 diabetes: challenges and possibilities.Diabetologia · 2025Review
- Genome Variability for the Development of Coronary Heart Disease in Type 2 Diabetes Mellitus: A Bibliometric Analysis.Journal of multidisciplinary healthcare · 2024Article
- Type 2 Diabetes Modifies the Association of CAD Genomic Risk Variants With Subclinical Atherosclerosis.Circulation. Genomic and precision medicine · 2023Article
- Article
- Genome-Wide Association Study of Peripheral Artery Disease.Circulation. Genomic and precision medicine · 2021Article
- Genetics of macrovascular complications in type 2 diabetes.World journal of diabetes · 2021Review
Corrections and comments
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Authors and funding
58 authors at 20 institutions in 17 countries.
Natalie R van ZuydamPat Macpherson Center for Pharmacogenetics & Pharmacogenomics, Cardiovascular & Diabetes Medicine (N.R.v.Z., C.N.A.P.), School of Medicine, University of Dundee.
Claes LadenvallDepartment of Clinical Sciences, Diabetes & Endocrinology, Lund University Diabetes Center, Malmö, Sweden (C.L., L.G.).
Benjamin F VoightDepartment of Systems Pharmacology & Translational Therapeutics (B.F.V.).
Rona J StrawbridgeCardiovascular Medicine Unit, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden (R.J.S., A.H.).
Juan Fernandez-TajesWellcome Center for Human Genetics (N.R.v.Z., J.F.T., N.W.R., N.R.R, A. Mahajan, A.G., H.W., A.P.M., M.I.Mc), University of Oxford, United Kingdom.
N William RaynerOxford Center for Diabetes, Endocrinology & Metabolism, Radcliffe Department of Medicine (N.R.v.Z., N.W.R., N.R.R., A. Mahajan, M.I.Mc), University of Oxford, United Kingdom.
Neil R RobertsonOxford Center for Diabetes, Endocrinology & Metabolism, Radcliffe Department of Medicine (N.R.v.Z., N.W.R., N.R.R., A. Mahajan, M.I.Mc), University of Oxford, United Kingdom.
Anubha MahajanOxford Center for Diabetes, Endocrinology & Metabolism, Radcliffe Department of Medicine (N.R.v.Z., N.W.R., N.R.R., A. Mahajan, M.I.Mc), University of Oxford, United Kingdom.
Efthymia VlachopoulouTransplantation Laboratory, Haartman Institute (E.V.), University of Helsinki, Helsinki, Finland.
Anuj GoelWellcome Center for Human Genetics (N.R.v.Z., J.F.T., N.W.R., N.R.R, A. Mahajan, A.G., H.W., A.P.M., M.I.Mc), University of Oxford, United Kingdom.
Marcus E Kleber
Christopher P NelsonDepartment of Cardiovascular Sciences, University of Leicester (C.P.N., N.J.S.).
Lydia Coulter KweeDuke Molecular Physiology Institute, Duke University, Durham, NC (L.C.K., S.H.S.).
Tõnu EskoEstonian Genome Center (T.E., E.M., R.M., L.M., K.F., M.P., A. Metspalu), University of Tartu, Tartu, Estonia.
Evelin MihailovEstonian Genome Center (T.E., E.M., R.M., L.M., K.F., M.P., A. Metspalu), University of Tartu, Tartu, Estonia.
Reedik MägiEstonian Genome Center (T.E., E.M., R.M., L.M., K.F., M.P., A. Metspalu), University of Tartu, Tartu, Estonia.
Lili MilaniEstonian Genome Center (T.E., E.M., R.M., L.M., K.F., M.P., A. Metspalu), University of Tartu, Tartu, Estonia.
Krista FischerEstonian Genome Center (T.E., E.M., R.M., L.M., K.F., M.P., A. Metspalu), University of Tartu, Tartu, Estonia.
Stavroula KanoniCenter for Genomic Health (S.K.), Queen Mary University of London, London, United Kingdom.
Jitender KumarDepartment of Medical Sciences, Molecular Epidemiology & Science for Life Laboratory (J.K., C.S., E.I.).
Ci SongDepartment of Medical Sciences, Molecular Epidemiology & Science for Life Laboratory (J.K., C.S., E.I.).
Jaana A HartialaDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (J.A.H.).
Nancy L PedersenDepartment of Medical Epidemiology & Biostatistics, Karolinska Institutet, Stockholm, Sweden (N.L.P.).
Markus PerolaResearch Program for Clinical & Molecular Metabolism, Faculty of Medicine (M.P.), University of Helsinki, Helsinki, Finland. Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Christian GiegerGerman Center for Diabetes Research (DZD), München-Neuherberg (C.G., A.P., H.G.).
Annette PetersGerman Center for Diabetes Research (DZD), München-Neuherberg (C.G., A.P., H.G.).
Liming QuCardiovascular Institute, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA (L.Q., M.P.R.).
Sara M WillemsDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands (S.M.W., C.v.D.).
Alex S F DoneyDivision of Molecular & Clinical Medicine (A.S.F.D.), School of Medicine, University of Dundee.
Andrew D MorrisThe Usher Institute of Population Health Sciences & Informatics (A.D.M.), University of Edinburgh, Edinburgh, U.K.
Yan ZhengDepartment of Nutrition (Y.Z., F.B.H., L.Q.).
Giorgio SestiUniversity "Magna Graecia" of Catanzaro, Italy (G.S.).
Frank B HuDepartment of Nutrition (Y.Z., F.B.H., L.Q.).
Lu QiCardiovascular Institute, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA (L.Q., M.P.R.).
Markku LaaksoFaculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland (M.L.).
Unnur ThorsteinsdottirFaculty of Medicine, University of Iceland. deCODE Genetics, Reykjavik, Iceland (U.T.).
Harald GrallertGerman Center for Diabetes Research (DZD), München-Neuherberg (C.G., A.P., H.G.).
Cornelia van DuijnDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands (S.M.W., C.v.D.).
Muredach P ReillyCardiovascular Institute, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA (L.Q., M.P.R.).
Erik IngelssonDepartment of Medical Sciences, Molecular Epidemiology & Science for Life Laboratory (J.K., C.S., E.I.).
Panos DeloukasWilliam Harvey Research Institute, Barts & the London Medical School (S.K., P.D.), Queen Mary University of London, London, United Kingdom.
Sek KathiresanCenter for Genomic Health (S.K.), Queen Mary University of London, London, United Kingdom.
Andres MetspaluEstonian Genome Center (T.E., E.M., R.M., L.M., K.F., M.P., A. Metspalu), University of Tartu, Tartu, Estonia.
Svati H ShahDivision of Cardiology, Department of Medicine, Duke University Medical Center (S.H.S.).
Juha SinisaloHeart & Lung Center, Helsinki University Hospital (J.S.) and Institute for Molecular Medicine Finland (FIMM), Helsinki University, Helsinki, Finland.
Veikko SalomaaNational Institute for Health and Welfare, Helsinki, Finland (M.P., V.S.).
Anders HamstenCardiovascular Medicine Unit, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden (R.J.S., A.H.).
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester (C.P.N., N.J.S.).
Winfried MärzSynlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany (W.M.).
Stanley L HazenLerner Research Institute, Heart & Vascular Institute, Cleveland Clinic, Cleveland, OH (S.L.H.).
Hugh WatkinsWellcome Center for Human Genetics (N.R.v.Z., J.F.T., N.W.R., N.R.R, A. Mahajan, A.G., H.W., A.P.M., M.I.Mc), University of Oxford, United Kingdom.
Danish SaleheenDepartment of Biostatistics & Epidemiology, University of Pennsylvania, Philadelphia, PA (D.S.).
Andrew P MorrisWellcome Center for Human Genetics (N.R.v.Z., J.F.T., N.W.R., N.R.R, A. Mahajan, A.G., H.W., A.P.M., M.I.Mc), University of Oxford, United Kingdom.
Helen M ColhounMRC Institute of Genetics & Molecular Medicine (H.M.C.), University of Edinburgh, Edinburgh, U.K.
Leif GroopDepartment of Clinical Sciences, Diabetes & Endocrinology, Lund University Diabetes Center, Malmö, Sweden (C.L., L.G.).
Mark I McCarthyOxford Center for Diabetes, Endocrinology & Metabolism, Radcliffe Department of Medicine (N.R.v.Z., N.W.R., N.R.R., A. Mahajan, M.I.Mc), University of Oxford, United Kingdom.
Colin N A PalmerPat Macpherson Center for Pharmacogenetics & Pharmacogenomics, Cardiovascular & Diabetes Medicine (N.R.v.Z., C.N.A.P.), School of Medicine, University of Dundee.
SUMMIT Steering Committee; CARDIOGRAMplusC4D Steering Committee*
Centre for Human Genetics · GBUniversity of Tartu · EEOxford Centre for Diabetes, Endocrinology and Metabolism · GBHelmholtz Zentrum München · DELund University · SETulane University · USBroad Institute · USDuke University · USErasmus MC · NLKarolinska University Hospital · SENHS Fife · GBUniversity of Leicester · GBAmity University · INBrigham and Women's Hospital · USCardiovascular Institute of the South · USCenter for Non-Communicable Diseases · PKCleveland Clinic Lerner College of Medicine · USdeCODE Genetics (Iceland) · ISFinnish Institute for Health and Welfare · FIFudan University · CN
Funding
Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI GREENBERG, ANDREW S, PERISSI, VALENTINA · 1992 to 2021
$25.0MGut Flora Metabolism of Dietary Phosphatidylcholine and CVDR01HL103866 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L · 2010 to 2023
$10.8MAlgorithms to identify non-coding mutational burden and disease-relevant pathwaysR01DK101478 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI VOIGHT, BENJAMIN FRANKLIN · 2014 to 2018
$2.9MInterstitial Cystitis in Swedish TwinsU01DK066134 · NIDDK · KAROLINSKA INSTITUTE · PI PEDERSEN, NANCY L · 2004 to 2008
$2.9MBeyond GWAS of insulin resistance: An integrated approach to translate genetic association to functionR01DK106236 · NIDDK · STANFORD UNIVERSITY · PI KNOWLES, JOSHUA WILEY · 2016 to 2020
$2.4MIntegrating genome-scale data to reveal causal mechanisms in type 2 diabetesU01DK105535 · NIDDK · UNIVERSITY OF OXFORD · PI GLOYN, ANNA LOUISE · 2015 to 2019
$1.7MAlgorithms to identify non-coding mutational burden and disease-relevant pathwaysR56DK101478 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI VOIGHT, BENJAMIN FRANKLIN · 2019 to 2019
$272kBritish Heart Foundation RG/14/5/30893Medical Research Council MC_PC_13040NHLBI NIH HHS R01 HL103866NIDDK NIH HHS P30 DK046200NIDDK NIH HHS R01 DK101478NIDDK NIH HHS R01 DK106236NIDDK NIH HHS R56 DK101478NIDDK NIH HHS U01 DK066134NIDDK NIH HHS U01 DK105535Wellcome Trust 212945/Z/18/Z
Abstract
backgroundCoronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D).
methodsTo test whether this reflects differential genetic influences on CAD risk in subjects with T2D, we performed a systematic assessment of genetic overlap between CAD and T2D in 66 643 subjects (27 708 with CAD and 24 259 with T2D). Variants showing apparent association with CAD in stratified analyses or evidence of interaction were evaluated in a further 117 787 subjects (16 694 with CAD and 11 537 with T2D).
resultsNone of the previously characterized CAD loci was found to have specific effects on CAD in T2D individuals, and a genome-wide interaction analysis found no new variants for CAD that could be considered T2D specific. When we considered the overall genetic correlations between CAD and its risk factors, we found no substantial differences in these relationships by T2D background.
conclusionsThis study found no evidence that the genetic architecture of CAD differs in those with T2D compared with those without T2D.
Indexed as
Genetic Predisposition to DiseaseCase-Control StudiesCoronary Artery DiseaseDiabetes Mellitus, Type 2Genome-Wide Association StudyHumansMeta-Analysis as TopicPolymorphism, GeneticRisk Factorsblood pressurecoronary artery diseasediabetes mellitusgenome-wide association studyrisk factors
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