Evidence map›Paper›PMID 33321047›Full record

ArticleAmerican journal of respiratory and critical care medicine2021

Secretory Cells Dominate Airway CFTR Expression and Function in Human Airway Superficial Epithelia.

Kenichi Okuda, Hong Dang, Yoshihiko Kobayashi, Gianni Carraro, Satoko Nakano, Gang Chen, Takafumi Kato, Takanori Asakura, Rodney C Gilmore, Lisa C Morton and 21 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed
13.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

138 citing papers in PubMed, 191 citations in OpenAlex.

  1. Epigenetic regulation and chromatin organization in cystic fibrosis airways.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2026
    Review
  2. Molecular therapy. Nucleic acids · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Considerations for early life genetic therapies in cystic fibrosis.American journal of physiology. Lung cellular and molecular physiology · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. FUT1- and GAL3ST2-mediated cellular glycan remodeling broadly restricts sialic acid-dependent viral infections.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  12. Article
  13. Article
  14. Airway epithelial heterogeneity and mucus plugging in asthmatic bronchioles.American journal of respiratory and critical care medicine · 2026
    Article
  15. Article
  16. Review
  17. Review
  18. Don't Stress: We're One Step Closer to Host-Directed Therapy for Influenza.American journal of respiratory cell and molecular biology · 2026
    Article
  19. Review
  20. The Challenges of Detecting Neutrophil CFTR.Journal of innate immunity · 2026
    Review

78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

31 authors at 7 institutions in 2 countries.

Kenichi OkudaMarsico Lung Institute/Cystic Fibrosis Research Center and.ORCID 0000-0001-9341-2730
Hong DangMarsico Lung Institute/Cystic Fibrosis Research Center and.
Yoshihiko KobayashiDepartment of Cell Biology, School of Medicine, Duke University, Durham, North Carolina.
Gianni CarraroDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
Satoko NakanoMarsico Lung Institute/Cystic Fibrosis Research Center and.
Gang ChenMarsico Lung Institute/Cystic Fibrosis Research Center and.
Takafumi KatoMarsico Lung Institute/Cystic Fibrosis Research Center and.
Takanori AsakuraMarsico Lung Institute/Cystic Fibrosis Research Center and.
Rodney C GilmoreMarsico Lung Institute/Cystic Fibrosis Research Center and.
Lisa C MortonMarsico Lung Institute/Cystic Fibrosis Research Center and.
Rhianna E LeeMarsico Lung Institute/Cystic Fibrosis Research Center and.
Teresa MascenikMarsico Lung Institute/Cystic Fibrosis Research Center and.
Wei-Ning YinMarsico Lung Institute/Cystic Fibrosis Research Center and.
Selene Margarita Barbosa CardenasMarsico Lung Institute/Cystic Fibrosis Research Center and.
Yvonne K O'NealMarsico Lung Institute/Cystic Fibrosis Research Center and.
Caroline E MinnickMarsico Lung Institute/Cystic Fibrosis Research Center and.
Michael ChuaMarsico Lung Institute/Cystic Fibrosis Research Center and.
Nancy L QuinneyMarsico Lung Institute/Cystic Fibrosis Research Center and.
Martina GentzschMarsico Lung Institute/Cystic Fibrosis Research Center and.
Carlton W AndersonCenter for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Andrew GhioClinical Research Branch, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Chapel Hill, North Carolina.
Hirotoshi MatsuiCenter for Respiratory Disease, National Hospital Organization Tokyo Hospital, Kiyose, Tokyo, Japan; and.
Takahide NagaseDepartment of Respiratory Medicine, The University of Tokyo, Tokyo, Japan.
Lawrence E OstrowskiMarsico Lung Institute/Cystic Fibrosis Research Center and.
Barbara R GrubbMarsico Lung Institute/Cystic Fibrosis Research Center and.
John C OlsenMarsico Lung Institute/Cystic Fibrosis Research Center and.
Scott H RandellMarsico Lung Institute/Cystic Fibrosis Research Center and.
Barry R StrippDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
Purushothama Rao TataDepartment of Cell Biology, School of Medicine, Duke University, Durham, North Carolina.
Wanda K O'NealMarsico Lung Institute/Cystic Fibrosis Research Center and.
Richard C BoucherMarsico Lung Institute/Cystic Fibrosis Research Center and.
Lung Institute · USCedars-Sinai Medical Center · USDuke University · USEnvironmental Protection Agency · USThe University of Tokyo · JPTokyo National Hospital · JPUniversity of North Carolina at Chapel Hill · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Temitope O. Keku · 1985 to 2026
$30.5M
Vector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Martina Gentzsch · 2004 to 2026
$26.5M
Role of Surfactant Proteins in Mediating Noninfectious Inflammatory and FibroproP01HL108793 · NHLBI · DUKE UNIVERSITY · PI JIANG, DIANHUA · 2012 to 2022
$21.3M
Mechanisms of submucosal gland cell mediated airway regenerationR01HL146557 · NHLBI · DUKE UNIVERSITY · PI TATA, PURUSHOTHAMA RAO · 2019 to 2023
$2.0M
Training Program in Cellular Systems and Integrative PhysiologyT32GM133364 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Kathleen M Caron, Natasha T Snider · 2020 to 2026
$1.4M
A Ciliated Cell-Specific Promoter for Gene Therapy of CFR01HL070199 · NHLBI · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI OSTROWSKI, LAWRENCE E · 2002 to 2005
$1.2M
To define the role of SOX9 and Sox9+ cells in alveolar homeostasis and regenerationR00HL127181 · NHLBI · DUKE UNIVERSITY · PI TATA, PURUSHOTHAMA RAO · 2017 to 2019
$738k
NCI NIH HHS P30 CA016086NHLBI NIH HHS P01 HL108793NHLBI NIH HHS R00 HL127181NHLBI NIH HHS R01 HL070199NHLBI NIH HHS R01 HL146557NIDDK NIH HHS P30 DK034987NIDDK NIH HHS P30 DK065988NIGMS NIH HHS T32 GM133364
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Case-Control StudiesCell Culture TechniquesCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorEpithelial CellsHumansRespiratory MucosaCFTR protein, humanCystic Fibrosis Transmembrane Conductance Regulatorairway secretory cellsCFTRionocytessingle-cell RNA sequencing

Identifiers

PMID33321047
PMCPMC8456462
OpenAlexW3113075930

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.